白细胞介素-8基因251 A/T位点的多态性与亚洲人群胃癌易感性的Meta分析

Interleukin-8251 A/T polymorphism and gastric cancer susceptibility in Asians population:a Meta-analysis

[目的]用Meta分析的方法评价IL-8基因251 A/T位点的多态性与亚洲人群胃癌易感性的关系。[方法]检索Web of science、PubMed、EMBASE、万方数据库、中国生物医学文献数据库、中文科技期刊数据库、中国期刊全文数据库,日期均从各数据库开始建库至2018年1月。全面检索IL-8基因251 A/T位点的多态性与胃癌易感性的病例对照研究文献,采用STATA统计软件进行Meta分析。[结果]最终纳入15篇病例对照研究进行Meta分析,共计3738例胃癌患者、4497例健康对照者。分析结果显示,IL-8基因251 A/T位点在等位基因模型(A vs T:OR=1.12;95%CI为1.04~1.21;P=0.002)、共显性模型(AA vs AT:OR=1.15;95%CI为1.00~1.32;P=0.050)、相加模型(AA vs TT:OR=1.36;95%CI为1.18~1.57;P=0.000)、相加模型(AT vs TT:OR=1.23;95%CI为1.11~1.36;P=0.000)、显性模型(AA vs AT+TT:OR=1.23;95%CI为1.08~1.40;P=0.002)、隐性模型(TT vs AA+AT:OR=1.26;95%CI为1.15~1.39)下均与亚洲人群胃癌易感性有关。[结论]IL-8基因251 A/T位点多态性与亚洲人群胃癌的易感性相关。

[Objective]To assess the association between Interleukin-8(IL-8)251 A/T polymorphism and gastric cancer susceptibility in Asians population by using meta-analysis.[Methods]We searched Web of science,PubMed,EMBASE,Chinese Biomedical Literature Database,Wanfang database,Chinese Science and Technology Academic Journal,Chinese Journal Full-text Database from their inception to January 2018 to identify relevant case-control study.Meta-analysis was performed using STATA software.[Results]A total of 15 case-control studies were included in this Meta-analysis,including3738 cases and 4497 controls.There was association between IL-8251 A/T polymorphism and gastric cancer susceptibility under allele genetic model(A vs T:OR=1.12;95%CI=1.04-1.21;P=0.002),codominant model(AA vs AT:OR=1.15;95%CI=1.00-1.32;P=0.050),additive model(AA vs TT:OR=1.36;95%CI=1.18-1.57;P=0.000),additive model(AT vs TT:OR=1.23;95%CI=1.11-1.36;P=0.000),dominant model(AA vs AT+TT:OR=1.23;95%CI=1.08-1.40;P=0.002)and recessive model(TT vs AA+AT:OR=1.26;95%CI=1.15-1.39;P=0.000).[Conclusion]IL-8251 A/T polymorphism may be associated with gastric cancer susceptibility for Asians population.