健康体检人群超重、肥胖与视网膜动脉硬化的关系研究

Study on relationship between overweight,obesity and retinal arteriosclerosis among population undergoing healthy physical examination

目的探讨超重、肥胖与视网膜动脉硬化之间的关系。方法选择2018年6-9月在北京市体检中心进行健康体检的人群为研究对象。收集体检对象的一般资料、既往病史及实验室检查指标,评估视网膜动脉硬化情况。多因素logistic回归分析体检人群视网膜动脉硬化的独立危险因素。结果本研究共纳入体检对象1458人,平均年龄49(41,58)岁,正常组641人(44.0%),超重组588人(40.3%),肥胖组229人(15.7%)。超重、肥胖组腰围、臀围、收缩压(SBP)、舒张压(DBP),以及合并高血压、糖尿病、视网膜动脉硬化的比例高于正常组,差异有统计学意义(P<0.05)。血红蛋白(HGB)、白细胞(WBC)、清蛋白(ALB)、肌酐(CRE)等临床指标3组比较,差异无统计学意义(P>0.05)。多因素logistic回归分析显示,超重和肥胖是视网膜动脉硬化的独立危险因素,年龄增加、血压高、合并糖尿病、尿蛋白阳性、颈动脉斑块也是视网膜动脉硬化的独立危险因素。结论视网膜动脉硬化在超重和肥胖人群中的发生率明显升高,需注意其血压、血糖、血脂等指标的评估与干预。

Objective To explore the relationship between overweight,obesity and retinal arteriosclerosis.Methods The population undergoing the healthy physical examination in Beijing Municipal Physical Examination Center from June 2018 to September 2018 were selected as the study subjects.The general data,past medical history and laboratory examination indexes of the subjects were collected,and the condition of retinal arteriosclerosis was evaluated.The multivariate logistic regression was used to analyze the independent risk factors of retinal arteriosclerosis in the population undergoing physical examination.Results A total of 1458 subjects were included in this study,with an average age of 49(41,58)years old,there were 641 persons(44.0%)in the normal group,588 persons(40.3%)in the overweight group and 229 persons(15.7%)in the obesity group.The overweight,waist circumference,hip circumference,systolic blood pressure(SBP),diastolic blood pressure(DBP),and the proportions of subjects complicated with hypertension,diabetes and retinal arteriosclerosis in the overweight and obesity groups were higher than those in the normal group,and the differences were statistically significant(P<0.05).The clinical indicators such as hemoglobin(HGB),white blood cells count(WBC),albumin(ALB)and creatinine(CRE)had no statistical difference among 3 groups(P>0.05).The multivariate logistic regression analysis showed that overweight and obesity were the independent risk factors for retinal arteriosclerosis.The age increase,high blood pressure,complicating diabetes,positive urine protein and carotid arterial plaque were also the independent risk factors of retinal arteriosclerosis.Conclusion The incidence of retinal arteriosclerosis in overweight and obese people is significantly increased.The attention should be paid to the evaluation and intervention of the indicators such as blood pressure,blood glucose and blood lipid.