我国首例Paraconiothyrium cyclothyrioides感染致眼内炎的相关研究

The first case of endophthalmitis caused by Paraconiothyrium cyclothyrioides in China

目的报道我国首例由Paraconiothyrium cyclothyrioides引起的真菌性眼内炎,并分析其生物学特征、感染途径及治疗方法。方法通过形态学鉴定、生长温度试验、ITS测序等方法对我院1株眼外伤患者左眼前房沉积物中培养分离到的丝状真菌进行鉴定。结果该丝状真菌在PDA平板上在25℃生长快速,可见灰橄榄色周边有白色绒毛状菌落,表面皱褶,35℃生长缓慢,可见黄豆大小白色凸起菌落;25℃及35℃培养后镜下可见大量结节状菌丝,未见分生孢子,属于不产孢株;ITS测序结果为Paraconiothyrium cyclothyrioides。结论本病例是国内首次报导的由Paraconiothyrium cyclothyrioides引起的真菌性眼内炎。

Objective To report the first case of endophthalmitis caused by Paraconiothyrium cyclothyrioides in China and analyze the fungal biological characteristics,infection routes and treatment.Methods The strain was isolated from anterior chamber sediment of the injured left eye,and was identified based on growth temperature,microscopic morphologies and ITS sequence analysis.Results The strain grew well at 25℃,and the macroscopic morphology on PDA showed a woolly grayish-white colony and folded surface.But the strain grew slowly at 35℃with soybean-size white convex colony.After cultivation at 25℃and 35℃numerous nodular hyphae were found under the microscope,and no conidia were observed.ITS sequence analysis showed the strain was Paraconiothyrium cyclothyrioides.Conclusion This was the first report of endophthalmitis caused by Paraconiothyrium cyclothyrioides in China.