弯曲菌基因组学的研究进展

Research progress in Campylobacter genomic analysis

弯曲菌是世界范围内引起细菌性胃肠炎疾病的重要人兽共患病原菌,对公众健康造成严重威胁,其流行、传播、扩散的复杂性与基因组的高变异有关。全基因组测序(WGS)是一种基于基因水平的快速简便工具,可快速准确地进行物种鉴定、分析不同个体基因组间的差异、预测细菌耐药和毒力基因以及预测种群演化模型等。本文旨在对近年来全基因组测序在弯曲菌基因组学中的应用展开综述,以期为弯曲菌的流行和防控提供依据。

Campylobacter is an important zoonotic pathogen causing gastroenteritis worldwide,and poses a serious threat to public health.The complexity of prevalence,transmission,and diffusion is associated with high genomic variations of Campylobacter.Whole Genome Sequencing(WGS)is an efficient tool to identify species quickly and accurately,analyze the differences between different individual genomes,predict bacterial resistance,virulence genes and population evolution models on the genetic level.Here we review the application of the whole genome sequencing in Campylobacter genomic analysis to provide a basis for the prevalence and prevention of Campylobacter.