丁苯酞联合依达拉奉治疗非致残性脑梗死的效果及对患者神经功能的影响

The Effect of Butylphthalide Combined with Edaravone in the Treatment of Non-disabling Cerebral Infarction and Its Influence on Patients'Neurological Function

目的分析丁苯酞联合依达拉奉治疗非致残性脑梗死的临床效果,观察其对患者神经功能的影响。方法选择2018年1月~2019年12内我院50例非致残性脑梗死患者作为研究对象,按随机原则将其分为观察组与对照组,各25例,对照组接受依达拉奉治疗,观察组采用丁苯酞联合依达拉奉治疗,比较两组血清Hcy水平、神经功能评分、治疗效果及C反应蛋白水平差异。结果两组血清Hcy水平均较治疗前改善,且观察组优于对照组,差异有统计学意义(P<0.05);治疗后7、14 d,两组NIHSS评分均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后7、14 d,两组C反应蛋白水平均较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率高于对照组(100.00%vs 88.00%),差异有统计学意义(P<0.05)。结论丁苯酞联合依达拉奉治疗非致残性脑梗死疗效确切,有助于改善患者的神经功能和炎性反应,对促进患者康复有重要作用。

Objective To analyze the clinical effect of butylphthalide combined with edaravone in the treatment of non-disabling cerebral infarction,and observe its effect on patients'neurological function.Methods From January 2018 to December 2019,50 patients with non-disabling cerebral infarction in our hospital were selected as the research objects.According to the principle of randomization,they were divided into observation group and control group,each with 25 cases.The control group received edaravone treatment,and the observation group was treated with butylphthalide combined with edaravone.The differences in serum Hcy levels,neurological function scores,therapeutic effects and C-reactive protein levels were compared between the two groups.Results The levels of serum Hcy in the two groups were improved compared to before treatment,and the observation group was better than the control group,the difference was statistically significant(P<0.05);At 7 and 14 d after treatment,the NIHSS scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);At 7 and 14 d after treatment,the levels of C-reactive protein in the two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);The total effective rate of treatment in the observation group was higher than that in the control group(100.00%vs 88.00%),the difference was statistically significant(P<0.05).Conclusion The combination of butylphthalide and edaravone is effective in treating non-disabling cerebral infarction,which can help improve the patient's neurological function and inflammatory response,and play an important role in promoting the recovery of patients.