抗抑郁剂联合治疗在抑郁症中的研究进展

Advances in the study of antidepressants combination therapy in depression

抗抑郁剂联合治疗(combined therapy)策略即同时使用两种抗抑郁剂,是临床上经常使用的治疗选择,尤其是随着新一代抗抑郁剂的安全性显著提高。目前,选择性5-羟色胺再摄取抑制剂与不同抗抑郁剂联合使用已被广泛用于对单药治疗无效的患者。同时,为缩短起效时间,提高治愈率,也尝试将联合治疗应用于抑郁症的初始或早期治疗阶段。联合治疗策略在使患者受益的同时,也存在不良反应增加等方面的风险。因此,需要进一步评估在不同时期应用抗抑郁剂联合治疗策略的益处和风险。现就抗抑郁剂联合治疗抑郁症的临床研究进行综述,以期为抑郁症的联合用药治疗提供参考。

Antidepressant combined therapy strategy,that is,the use of two antidepressants at the same time,is a treatment option often used in clinic,especially with the significant improvement of the safety of the new generation of antidepressants.At present,the combination of selective serotonin reuptake inhibitors and different antidepressants has been widely used in patients who do not respond to monotherapy.At the same time,in order to shorten the onset time and improve the cure rate,the combination therapy has also been applied to the initial or early treatment stage of depression.Combined treatment strategy benefits patients,but also has the risk of increasing adverse reactions.Therefore,it is necessary to further evaluate the benefits and risks of antidepressant combination therapy in different periods.This article reviews the clinical research of antidepressant combination therapy for depression,in order to provide reference for the combination therapy of depression.