摘要
麻醉药物具有神经保护作用,同时也有一定的神经毒性,如何实现其神经保护作用,减少神经毒性,成为临床麻醉医生面临的重要难题。本文从麻醉药物的作用分子靶点、神经保护作用、神经毒性以及如何减轻神经毒性等方面进行了综述,以期为临床麻醉用药选择提供参考。
Anesthetics possess neuroprotective effects but also certain neurotoxicity.How to achieve neuropro⁃tection and reduce neurotoxicity concurrently has become an important problem for anesthesiologists.This article re⁃views the molecular targets,neuroprotective effects,and neurotoxicity of anesthetics,as well as how to reduce the neurotoxicity of anesthetics,in order to provide a reference for the selection of anesthetics in clinical practice.
作者
胡雨蛟
吴安国
欧册华
HU Yujiao;WU Anguo;OU Cehua(Department of Anesthesia,Luzhou 646000,Sichuan Province,China;Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chi-nese Materia Medica,School of Pharmacy,Luzhou 646000,Sichuan Province,China;Department of Pain of Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China)
出处
《西南医科大学学报》
2021年第2期181-186,共6页
Journal of Southwest Medical University
基金
国家自然科学基金青年基金项目(81903829)
国家级大学生创新创业训练计划项目(202010632047)
泸州市人民政府-西南医科大学联合项目(2018LZXNYD-ZK42)。
关键词
麻醉药物
神经保护
神经毒性
中枢神经系统
Anesthetics
Neuroprotection
Neurotoxicity
Central nervous system
