^(131) I联合甘氨双唑钠治疗分化型甲状腺癌骨转移的临床疗效

Clinical effect of the combination of ^(131) I and sodium glycididazole in the treatment of differentiated thyroid cancer with bone metastasis

目的探讨^(131) I联合甘氨双唑钠治疗分化型甲状腺癌(differentiated thyroid carcinoma,DTC)骨转移的临床疗效。方法以我院96例DTC骨转移患者为研究对象,随机分为对照组和观察组各48例,对照组仅予^(131) I治疗,观察组予^(131) I联合甘氨双唑钠治疗,比较两组的临床疗效、转移灶清除效果及不良反应。结果根据骨痛评价标准,观察组的有效率(71.00%)高于对照组(48.00%)(P<0.05)。根据血清甲状腺球蛋白(thyroglobulin,Tg)评价标准,观察组的有效率(77.00%)高于对照组(58.00%)(P<0.05)。根据病灶影像学评价标准,观察组的有效率(48.00%)高于对照组(27.00%)(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论^(131) I联合甘氨双唑钠可提高DTC骨转移患者临床疗效,具有临床推广意义。

Objective To explore the clinical effect of ^(131) I combined with sodium glycididazole in the treatment of differentiated thyroid cancer(DTC)with bone metastasis.Methods Ninty-six patients with DTC bone metastasis were randomly divided into the control group and the observation group,forty-eight patients in each group.The control group was treated with ^(131) I only,while the observation group was treated with ^(131) I combined with glycididazole sodium.The clinical effect,metastasis clearance effect and adverse reactions of the two groups were compared.Results The effective rate of the observation group(71.00%)was higher than that of the control group(48.00%)(P<0.05)according to the evaluation criteria of bone pain.The effective rate of the observation group(77.00%)was higher than that of the control group(58.00%)(P<0.05)according to the evaluation criteria of serum thyroglobulin(Tg).The effective rate of the observation group(48.00%)was higher than that of the control group(27.00%)(P<0.05)according to the imaging evaluation criteria.There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of ^(131) I and sodium glycidazole can improve the clinical effect of patients with DTC bone metastasis,which has clinical significance for promotion.