度洛西汀联合氟比洛芬巴布膏用于非特异性肋软骨炎患者的观察

Observation of Duloxetine Combined with Flurbiprofen Cataplasms in Patients with Nonspecific Costochondritis

目的观察度洛西汀联合氟比洛芬巴布膏治疗非特异性肋软骨炎的疗效。方法选取非特异性肋软骨炎患者120例,按随机数字表法分为A、B两组,每组60例。A组联合应用度洛西汀和氟比洛芬巴布膏;B组单独使用氟比洛芬巴布膏。于治疗前和治疗后1、3、7d由专业医师在双盲条件下采用视觉模拟评分法(VAS)对两组患者进行疼痛程度评分,并于治疗7d后对两组行疗效评定。结果治疗后1、3、7d,两组患者的VAS评分与组内治疗前比较,差异均有统计学意义(P<0.05)。治疗后,A组患者痊愈40例(66.7%),显效8例(20%),好转2例(3.3%),痊愈率显著高于B组,差异均有统计学意义(P<0.05)。结论度洛西汀联合氟比洛芬巴布膏可较快缓解非特异性肋软骨炎患者的疼痛症状,短期治愈率高。

Objective To observe the efficacy of duloxetine combined with Flurbiprofen Cataplasms in the treatment of nonspecific costochondritis.Methods One hundred and twenty patients with nonspecific costal chondritis were selected and divided into group A and group B equally,which is 60 patients in each.Group A was combined with duloxetine and Flurbiprofen cataplasms,while group B was treated with Flurbiprofen cataplasms only.Before treatment and on 1,3,7 days after treatment,visual analogue scale(VAS)was used to score the pain degree of the two groups of patients by a professional physician in the double-blind condition,and evaluated the efficacy of two groups 7 days after treatment.Results After treatment 1,3,and 7 days,the VAS scores of two groups were significantly different from those before treatment in groups(P<0.05).After treatment,40 cases(66.7%)of patients in group A were cured,8 cases(20%)were markedly improved,and 2 cases(3.3%)were improved.The cure rate was significantly higher than that in group B,and the differences were statistically significant(P<0.05).Conclusion Duloxetine combined with Flurbiprofen cataplasms can relieve pain symptoms of patients with non-specific costochondritis quickly,and the short-term cure rate is high.