磷酸肌酸钠治疗小儿重症手足口并发心肌损害的疗效观察

Effect of sodium creatine phosphate in the treatment of severe hand foot mouth complicated with myocardial damage in children

目的探讨磷酸肌酸钠治疗小儿重症手足口并发心肌损害的临床治疗效果。方法选取2015年1月至2019年12月本院收治的手足口病并发心肌损害患儿60例,采用随机数表法分为研究组与对照组,每组30例。对照组给予基础治疗并静滴大剂量维生素C,研究组给予基础治疗上静滴磷酸肌酸钠,比较两组患儿的临床疗效和不良反应发生率。结果研究组治疗总有效率为96.67%,明显高于对照组的86.67%,差异有统计学意义(P<0.05)。研究组不良反应发生率为6.67%,明显低于对照组26.67%,差异有统计学意义(P<0.05)。结论磷酸肌酸钠治疗小儿手足口病并发心肌损害患者疗效显著,安全、可靠且无明显不良反应,值得临床推广应用。

Objective To explore the clinical effect of sodium creatine phosphate in the treatment of severe hand foot mouth complicated with myocardial damage in children.Methods From January 2015 to December 2019,60 cases of hand foot mouth disease with myocardial damage were selected.They were divided into study group and control group according to random number table method,with 30 cases in each group.The control group was given basic treatment and intravenous drip of large dose vitamin C,and the study group was given basis treatment and intravenous drip of sodium creatine phosphate.The clinical efficacy and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 96.67%,which was significantly higher than 86.67%of the control group(P<0.05).The incidence of adverse reactions in the study group was 6.67%,which was significantly lower than 26.67%in the control group(P<0.05).Conclusion The therapeutic effect of sodium creatine phosphate on children hand foot mouth disease complicated with myocardial damage is significant,safe,reliable and without obvious adverse reactions,which is worthy of clinical application.