快速老化SAMP8小鼠Aβ沉积的研究进展

The Research about AβDeposition in SAMP8 Mice

快速老化小鼠(senescence-accelerated mouse,SAM)是通过AKR/J系小鼠选择性培育的快速老化模型,SAMP8(senescence-accelerated mouse prone/8,SAMP8)小鼠表现出增龄性中枢神经退行性病理特征,常用于学习记忆缺陷及衰老相关机制研究。目前,发现β淀粉样蛋白(β-Amyloid,Aβ)沉积是影响SAMP小鼠衰老的重要机制之一,其表达量随年龄增长而递增,因此SAMP8小鼠衰老的学习记忆障碍发生机制以减少脑内Aβ沉积为主。

The senescence-accelerated mouse(SAM)is anaccelerated aging model that isspontaneously developed fromAKR/J mice by Takeda at the University of Kyoto.Senescence accelerated mouse prone 8(SAMP8)mice present the aging-related-neurodegenerativecharacteristics,whichcommonly used for researching the mechanism of learning and memory impairment.Previous studies have found that Aβcascade hypothesis of SAMP mice is one of the most important pathogenesis,and the Aβexpression increased with age.Therefore,the mainly mechanism study is to reduce the impairment of Aβdeposition on the learning and memory in SAMP8 mice.