布地奈德结合阿奇霉素序贯治疗对支原体肺炎患儿血清GM CSF、CXCL8水平的影响

Effect of sequential treatment with budesonide and azithromycin on serum GM CSF and CXCL8 levels in children with mycoplasma pneumonia

目的探讨布地奈德结合阿奇霉素序贯治疗对支原体肺炎患儿的临床疗效。方法回顾性分析2018年2月-2019年6月于本院接受治疗的85例支原体肺炎患儿的临床资料,视其药物治疗方案的不同分为对照组(基础治疗+阿奇霉素序贯治疗,42例)和观察组(基础治疗+阿奇霉素序贯治疗+布地奈德,43例)两组。两组均连续治疗2周,观察两组患者临床症状消失时间、住院时间,并对比两组患者治疗前后血清粒细胞-巨噬细胞集落刺激因子(GM CSF)、CXC趋化因子配体8(CXCL8)水平,同时记录两组入选者不良反应发生情况。结果与对照组相比,观察组发热、咳嗽、喘憋、肺部啰音消失时间及住院时间均更短,差异有统计学意义(P<0.05);治疗后,两组入选者血清GM CSF、CXCL8水平均低于治疗前,且与对照组相比,观察组更低,差异有统计学意义(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论布地奈德结合阿奇霉素序贯治疗支原体肺炎患儿效果良好,可有效缩短临床症状消失时间及住院时间,改善血清GM CSF、CXCL8水平,且不会增加不良反应。

Objective To explore the clinical effect of sequential treatment of budesonide combined with azithromycin on children with mycoplasma pneumonia.Methods The clinical data of 85 children with mycoplasma pneumonia those who were treated in our hospital from February 2018 to June 2019 were analyzed retrospectively.According to different drug treatment schemes,they were divided into control group(basic treatment+Azithromycin Sequential treatment,42 cases)and observation group(basic treatment+Azithromycin Sequential Treatment+budesonide,43 cases).Patients in both two groups were treated for 2 weeks,and the time of clinical symptoms disappearance and hospitalization were observed.The serum levels of granulocyte-macrophage colony stimulating factor(GM CSF)and CXC chemokine ligand 8(CXCL8)were compared before and after treatment,and the adverse reactions of the two groups were recorded.Results Compared with the control group,the time of fever,cough,asthma,lung rale disappearance and hospitalization in the observation group were shorter,the difference was statistically significant.After treatment the levels of CSF and CXCL8 in both groups were lower than those before treatment,and those in the observation group were lower in theose in the in the control group,the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusions Budesonide combined with sequential therapy of azithromycin is effective in the treatment of mycoplasma pneumonia.It could effectively shorten the time of clinical symptoms disappearance and hospitalization,improve the level of serum GM CSF and CXCL8,and will not increase the adverse reactions.