消退素在牙髓、根尖周及牙周组织炎症环境中的活髓保存及再生作用

Effects of resolvin on vital pulp conservation and regeneration during the inflammatory environment of dental pulp,periapical and periodontal tissues

背景:细菌感染是牙髓及根尖周组织感染的主要病因,保存活髓和再生牙髓逐渐成为临床治疗牙髓及根尖周疾病的重要研究方向。消退素(resolvin)是ω-3多不饱和脂肪酸衍生而来的脂质介质,具有促进组织炎症消退、炎症状态恢复的作用。目的:回顾消退素在炎症调控中的研究进展及其在牙髓、根尖周及牙周组织炎症中的应用,以期为临床牙髓组织炎症状态的恢复及再生提供研究基础。方法:应用计算机在PubMed数据库、维普数据库、万方数据库及中国知网(CNKI)中国期刊全文数据库检索2014年1月至2020年6月相关文献,以“消退素,作用,信号通路”为中文检索词,以“resolvin,effect,signaling pathway”为英文检索词,最终纳入35篇文献归纳总结消退素的作用;以“消退素,牙髓炎,根尖周炎,牙周炎,口腔”为中文检索词,以“resolvin,pulptitis,periapical,periodontitis,dental”为英文检索词,最终纳入31篇文献归纳总结消退素在口腔不同组织和疾病中的应用,其余3篇解释说明文章内容。结果与结论:文章系统回顾了消退素的种类及作用,详细回顾了消退素在牙髓、根尖周及牙周组织炎症性疾病中的作用及机制,为其临床应用于牙髓组织炎症后的活髓保存及再生提供研究依据。

BACKGROUND: Bacterial infection is an important cause of infection of the dental pulp and periapical tissue. Vital pulp conservation and regeneration of the dental pulp are becoming new clinical strategies for the treatment of pulp and periapical diseases. Resolvin is a lipid mediator derived from omega-3polyunsaturated fatty acids. It promotes the resolution of tissue inflammation and the recovery of inflammatory conditions.OBJECTIVE: To review the research progress in the effect of resolvin in inflammation regulation and its application in the inflammation of dental pulp, periapicaland periodontal tissues, providing evidence for inflammatory recovery and regeneration of the dental pulp.METHODS: PubMed, VIP, WanFang and CNKI were searched for relevant literatures published from January 2014 to June 2020 using the keywords of “resolvin,effect, signaling pathway” in Chinese and English, respectively. Thirty-five articles regarding resolvin and its application were included and analyzed. Thesedatabases were also searched using the keywords of “resolving, pulptitis, periapical, periodontitis, dental” in Chinese and English, and 31 articles were includedfor analyzing the application of resolving in different tissues and diseases, and another 3 articles were further explained of the literature content.RESULTS AND CONCLUSION: In this article, we systematically review the types and effects of resolvin, and detail the role and mechanism of resolvin ininflammatory diseases of the dental pulp, periapical and periodontal tissues. This will so provide the research basis for the preservation and regeneration ofvital pulp after its clinical use for dental inflammation.