中重度抑郁症患者心电图及心率变异性分析

Analysis of electrocardiogram and heart rate variability in patients with moderate to severe depression

目的:探讨中重度抑郁症患者心电图及心率变异性特点,为临床评估中重度抑郁症心脏自主神经功能变化提供依据。方法:选择2018年6月至2019年12月就诊于湖南省脑科医院的中重度抑郁症患者38例为研究组,32例健康志愿者为对照组,比较两组心电图异常率及心率变异性,并统计分析各指标之间的差异。结果:研究组心电图异常ST-T改变发生率明显高于对照组,差异具有统计学意义(44.7%比6.3%,P<0.05);研究组心率变异性时域指标SDNN、SDANN明显低于正常对照组,差异均具有统计学意义(P<0.05)。结论:中重度抑郁症患者心脏自主神经调节功能降低,心电图异常率高,以ST-T改变多见,易导致心血管疾病的发生,临床应早期进行心电图和心率变异分析检测,提高抑郁症诊疗效果。

Objective:To explore the characteristics of electrocardiogram(ECG)and heart rate variability(HRV)in patients with moderate to severe depressive disorder,and provide guidance for the study of cardiac autonomic nervous function.Methods:Thirty-eight patients with moderate to severe depression were enrolled as the study group,and 32 healthy volunteers as the control group.The abnormal rate of ECG and HRV were compared between the two groups.Results:The incidence rate of abnormal ST-T changes in the study group was significantly higher than that in the control group(44.7%vs.6.3%,P<0.05).The time domain indexes of heart rate variability SDNN and SDANN in the study group were significantly lower than those in the control group(P<0.05).Conclusions:Cardiac autonomic nerve regulation function is reduced and abnormal rate of ECG is high in patients with moderate to severe depression,especially ST-T changes,which can easily lead to cardiovascular disease.ECG and HRV analysis should be carried out in the early stage in order to improve the diagnosis and treatment effect of depression.