饮水卫生及习惯与胃癌发生的相关性分析

Correlation Analysis of Drinking Water Hygiene and Habits With Gastric Cancer

目的分析饮水卫生及习惯与胃癌发生的相关性。方法选择2017年2月至2020年5月在四川省达州市中西医结合医院接受治疗的胃癌初诊病例172例作为病例组,根据性别、年龄(±5岁)进行1∶1配比,选择同期健康体检的非胃癌患者172例作为对照组进行以医院为基础的病例⁃对照研究。采用自制问卷对患者的一般情况、饮食情况、饮水习惯进行调查,分析各因素对胃癌的影响。结果单因素基础上条件logistic回归分析结果显示有胃癌家族史(RR=4.586,95%CI=1.739~15.248)、有吸烟史(RR=3.644,95%CI=1.297~10.236)、有饮酒史(RR=3.770,95%CI=1.649~8.620)、有幽门螺杆菌感染史(RR=5.635,95%CI=2.018~15.737)、腌制食品摄入频率>1次/周(RR=5.551,95%CI=2.011~15.322)、饮水习惯只喝生水(RR=4.614,95%CI=2.062~10.325)为胃癌的危险因素,饮用水来源为经洁净处理的水(RR=0.161,95%CI=0.073~0.354)、每日饮水量1000~1500 mL(RR=0.203,95%CI=0.094~0.437)为保护因素(P<0.05)。结论胃癌的发生与饮水习惯、饮用水源、每日饮水量均密切相关,同时胃癌家族史、饮酒史、吸烟史、幽门螺杆菌感染史及腌制食品摄入情况也对胃癌的发生有重要的影响。

Objective To analyze the relationships between drinking water hygiene and habits and the occurrence of gastric cancer.Methods 172 newly diagnosed gastric cancer cases in Dazhou Integrated TCM&Western Medicine Hospital from February 2017 to May 2020 were selected as the case group.According to the gender and age(±5 years old),172 cases of non⁃gastric cancer patients who received healthy check⁃up in the same period were selected as the control group for a hospital⁃based case⁃control study.Self⁃made questionnaires were used to investigate the general condition,diet and drinking habits of patients,and analyze the influences of various factors on gastric cancer.Results On the basis of single factor analysis,multivariate conditional logistic regression analysis showed that family history of gastric cancer(RR=4.586,95%CI=1.739~15.248),smoking history(RR=3.644,95%CI=1.297~10.236),alcohol drinking history(RR=3.770,95%CI=1.649~8.620),Helicobacter pylori infection history(RR=5.635,95%CI=2.018~15.737),preserved food intake frequency>1 time/week(RR=5.551,95%CI=2.011~15.322),the habit of drinking raw water(RR=4.614,95%CI=2.062~10.325)were risk factors for gastric cancer.Purified drinking water source(RR=0.161,95%CI=0.073~0.354),daily 1000~1500 mL drinking water(RR=0.203,95%CI=0.094~0.437)were protective factors(P<0.05).Conclusions The occurrence of gastric cancer is closely related to drinking habits,drinking water sources,and daily drinking water quantity.Family history of gastric cancer,alcohol drinking history,smoking history,Helicobacter pylori infection history and preserved food intake also have an important impact on the occurrence of gastric cancer.