摘要
目的研究重度子痫患者血清胱抑素C(CysC)、胎盘生长因子(PLGF)和转化生长因子-β1(TGF-β1)水平变化及与孕周的相关性。方法对2017年2月至2019年2月期间内蒙古自治区妇幼保健院诊治的335例子痫前期患者作为观察组,选择同期进行健康体检的335例正常孕妇作为对照组。统计每组患者血清CysC、PLGF和TGF-β1水平,比较不同孕周及不同疾病程度患者血清CysC、PLGF和TGF-β1水平。分析血清CysC、PLGF和TGF-β1水平与发病孕周的相关性,并绘制发病孕周、血清CysC、PLGF和TGF-β1水平单独及联合诊断的ROC曲线。结果与对照组比较,观察组的血清CysC和TGF-β1水平明显提高(P<0.05),PLGF水平明显减少(P<0.05)。与轻度组比较,重度组患者CysC和TGF-β1水平明显提高(P<0.05),PLGF水平明显减少(P<0.05)。重度子痫患者血清CysC和TGF-β1水平与发病孕周呈正相关(r值分别为0.579和0.602;P<0.01),而PLGF水平与发病孕周呈负相关(r=-0.436;P<0.01)。结论在子痫患者中CysC和TGF-β1水平增加,PLGF水平下降。血清CysC、PLGF和TGF-β1水平与子痫严重程度和孕妇孕周密切相关,并且发病孕周联合血清CysC、PLGF和TGF-β1水平在重度子痫诊断中具有重要的临床意义。
Objective To investigate the changes of serum levels of cystatin C(CysC),PLGF and TGF-β1 and their correlation with gestational weeks in patients with severe eclampsia.Methods A total of 335 patients with preeclampsia who were treated in our hospital from February 2017 to February 2019 were enrolled as observation group,at the same tim,the other 335 normal pregnant women who underwent physical examination in our hospital were enrolled as control group.The serum levels of CysC,PLGF and TGF-β1 in patients in each group were counted,and serum levels of CysC,PLGF and TGF-β1 were detected and compared between the two groups.The correlation between the serum levels of CysC,PLGF and TGF-β1 and the onset gestational week was analyzed,and ROC curves for single and combined diagnosis of onset gestational week,serum levels of CysC,PLGF and TGF-β1 were drawn.Results As compared with those in control group,the serum levels of CysC and TGF-β1 in observation group were significantly increased(P<0.05),and PLGF levels were significantly decreased(P<0.05).As compared with those in mild case group,the levels of CysC and TGF-β1 in severe case group were significantly increased(P<0.05),and PLGF levels were significantly decreased(P<0.05).Moreover the serum levels of CysC and TGF-β1 in patients with severe eclampsia were positively correlated with onset gestational weeks(P<0.01),however,the PLGF levels were negatively correlated with the gestational weeks of onset(P<0.01).Conclusion The serum levels of CysC and TGF-β1 are increased and PLGF levels are decreased in patients with eclampsia,and the serum levels of CysC,PLGF and TGF-β1 are closely related to the severity of eclampsia and gestational weeks of the pregnant woman,moreover,the combined detection of serum levels of CysC,PLGF,TGF-β1 with gestational weeks plays an important role in the diagnosis of severe eclampsia.
作者
张俊绘
刘爱菊
冀云鹏
李跃飞
王婷婷
ZHANG Junhui;LIU Aiju;JI Yunpeng(Inner Mongolia Hospital for Maternal and Child Health, Inner Mongolia, Hohhot 010010,China)
出处
《河北医药》
CAS
2021年第6期824-827,832,共5页
Hebei Medical Journal
基金
内蒙古自治区自然科学基金(编号:2016D01C021)。
关键词
重度子痫
胱抑素C
胎盘生长因子
转化生长因子-β1
孕周
severe eclampsia
Cystatin C
placental growth factor
transforming growth factor-β1
gestational weeks