口腔幽门螺杆菌根除预防胃内幽门螺杆菌感染的多中心研究

Oral Helicobacter pylori eradication for prevention of gastric Helicobacter pylori infection:a multicenter study

目的探讨口腔幽门螺杆菌(Helicobacter pylori, H.pylori)阳性与胃内幽门螺杆菌感染的关系。方法选取口腔幽门螺杆菌阳性患者共计1 897例,按1∶1比例随机分为使用"无幽梅"牙膏组与普通牙膏组。两组分别接受"无幽梅"牙膏和普通牙膏,治疗时间为3个月。随后,重新分组,将口腔幽门螺杆菌阳性及阴性的患者各分为一组,1年后,行C呼气试验检查,分析两组患者胃内幽门螺杆菌感染情况。结果 1年后,口腔幽门螺杆菌阴性组胃内幽门螺杆菌感染率为0.62%;口腔幽门螺杆菌阳性组感染率为6.79%。两组统计差异具有显著性(P<0.01)。结论口腔幽门螺杆菌与胃内幽门螺杆菌密切相关,建议根除口腔幽门螺杆菌,使用公筷,避免幽门螺杆菌口口传播。

Objective To investigate the relationship between oral Helicobacter(H.) pylori positive and gastric H.pylori infection.Methods A total of 1 897 patients with oral H.pylori positive were selected and randomly divided into "Wu Youmei" toothpaste group and ordinary toothpaste group at the ratio of 1:1.The two groups received the treatment of "Wu Youmei" toothpaste and ordinary toothpaste with 3 months.Subsequently,patients were regrouped into with positive and negative oral H.pylori.One year later,C breath test was performed to analyze the H.pylori infection in the stomach of the two groups.Results After one year,the infection rate of H.pylori in the negative group was 0.62%,and that of the positive group was 6.79%.There was significant difference between the two groups(P<0.01).Conclusion Oral H.pylori is closely related to gastric H.pylori.It is suggested to eradicate oral H.pylori and use public chopsticks to avoid oral transmission of H.pylori.