红霉素栓联合阿奇霉素片治疗非淋菌性宫颈炎患者的效果

Effects of Erythromycin suppository combined with Azithromycin tablets in treatment of non-gonococcal cervicitis

目的:探讨红霉素栓联合阿奇霉素片治疗非淋菌性宫颈炎(NGC)患者的效果。方法:选取166例NGC患者为研究对象,按照随机数字表法分为观察组和对照组各83例。对照组口服阿奇霉素片,观察组在对照组基础上联合红霉素栓,比较两组临床疗效,治疗前及治疗7 d后的炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、不良反应发生率。结果:观察组治疗总有效率为98.80%,高于对照组的90.36%,差异有统计学意义(P<0.05);治疗后,两组hs-CRP、IL-6、TNF-α水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:红霉素栓联合阿奇霉素对NGC患者的疗效较好,可有效降低炎性因子水平,且安全性好。

Objective:To study effects of Erythromycin suppository combined with Azithromycin tablets in treatment of non-gonococcal cervicitis(NGC).Methods:166 NGC patients were selected and divided into observation group and control group according to the random number table method,83 cases in each group.The control group was given Azithromycin tablets orally,while the observation group was combined with Erythromycin suppository on the basis of that of the control group.The clinical efficacy,the inflammatory factor[high-sensitivity C-reactive protein(hs-CRP),interleukin 6(IL-6),tumor necrosis factorα(TNF-α)]levels before and 7 days after the treatment and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 98.80%,which was higher than 90.36%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of hs-CRP,IL-6 and TNF-αin the two groups decreased;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Erythromycin suppository combined with Azithromycin has a good effect on the NGC patients,and can effectively reduce the levels of inflammatory factors with good safety.