人工智能技术在鼻咽癌放疗危及器官自动勾画中的应用研究

Application of artificial intelligence technology in automatic delineation of organs at risk in nasopharyngeal carcinoma radiotherapy

目的评估基于人工智能技术的放疗危及器官自动勾画软件在临床应用中的价值。方法选取2019年4月—2020年4月在自贡市第一人民医院肿瘤科治疗的30例鼻咽癌患者进行研究。首先,使用AccuContour软件勾画30例鼻咽癌患者的危及器官;然后使用瓦里安Eclipse v13.6计划系统人为手工勾画危及器官;最后将自动勾画的危及器官和手工勾画的危及器官在Eclipse系统上进行对比,通过比较体积差异、位置差异、重合性差异、相似性差异等参数,评估自动勾画软件的几何精度,验证其应用于临床的可行性。结果以医师手工勾画为基准,AccuContour软件勾画的危及器官与手工勾画相比,小体积的危及器官体积差异较大,达到0.8,但位置差异较小,大体积的危及器官重合性和相似性较大,基本在0.7以上。自动勾画的危及器官某些CT层面与人工勾画相比会有较大差距。结论基于人工智能技术的放疗危及器官自动勾画软件在鼻咽癌危及器官勾画精度较高,经略微修改可以用于临床工作,能提高临床工作效率。

Objective The aim of this study was to evaluate the clinical value of the software for automatic delineation of organs at risk in radiotherapy based on artificial intelligence technology.Methods Thirty cases of nasopharyngeal carcinoma treated in the department of Oncology at Zigong First people′s Hospital from April 2019 and April 2020 were selected for the study.First,the AccuContour software was used to delineate the organs at risk(OARs)of 30 nasopharyngeal cancer patients,and then the Varian Eclipse v13.6 treatment planning system was used to manually delineate the OARs.Finally,the OARs automatically sketched and manually sketched were compared on the Eclipse system,and the geometric accuracy of the automatic sketching software was evaluated by comparing the volume difference,location difference,coincidence difference,similarity difference and other parameters,so as to verify its feasibility in the clinical application.Results Compared with manual delineation,the volume difference of small-size organs was larger,reaching 0.8,but the location difference was smaller.The coincidence and similarity of large size organs were larger,basically above 0.7.There was a big gap between automatic delineation and manual one in some CT sections of OARs.Conclusion The software based on artificial intelligence technology has a high accuracy in the delineation of organs at risk in nasopharyngeal carcinoma,and can be used in clinical work with slight modification,which can improve the efficiency of clinical work.