内质网应激在肝癌中的作用

The role of endoplasmic reticulum stress in liver cancer

内质网应激(Endoplasmic Reticulum Stress,ERS)是一种极其重要的信号反应通路。内质网应激时,首先启动生存途径即未折叠蛋白反应(Unfolded protein response,UPR),而长时间的内质网应激将会启动细胞凋亡途径。目前越来越多的研究表明,肝癌与内质网应激密切相关,并且肝癌的肿瘤微环境可使内质网产生应激已得到证实。根据相关文献报道的内质网双重作用,内质网应激既可以诱导转化肝癌,又可以抑制肝癌增殖、转移等,故内质网应激为肝癌新的治疗方法提供可能。本文就以内质网应激与肝癌关系的研究进展进行综述。

Endoplasmic reticulum stress(ERS)is an extremely important signal response pathway.When the ER is stressed,the survival pathway-the unfolded protein response(UPR)is first initiated,and the prolonged ERS will initiate the apoptosis pathway.At present,more and more studies have shown that liver cancer is closely related to ERS,and it has been confirmed that the tumor microenvironment of liver cancer can cause ERS.According to the dual role of ER reported in relevant literature,ERS can not only induce the transformation of liver cancer,but it also inhibits the proliferation and metastasis of liver cancer.Therefore,ERS provides the possibility of new treatment methods for liver cancer.This article reviews the research progress on the relationship between ERS and liver cancer.