PARP抑制剂治疗BRCA1/2突变转移性乳腺癌的研究进展

Research progress of PARP inhibitors in the treatment of BRCA1/2 mutation metastatic breast cancer

近些年PARP抑制剂成为治疗乳腺癌临床研究新热点,大量研究证实其在BRCA1/2突变转移性乳腺癌患者中获益。本文就PARP抑制剂的作用机制和几种PARP抑制剂治疗BRCA1/2突变转移性乳腺癌患者的研究进展进行综述。

In recent years,PARP inhibitors have become a new hot spot in clinical research on the treatment of breast cancer.A large number of studies have confirmed that they are beneficial in patients with BRCA1/2 mutant metastatic breast cancer.This article reviews the mechanism of PARP inhibitors and the research progress of several PARP inhibitors in the treatment of patients with BRCA1/2 mutated metastatic breast cancer.