TTK在肿瘤中的研究进展

Research progress of threonine and tyrosine kinase in tumor

苏氨酸和酪氨酸激酶(Threonine and tyrosine kinase,TTK)是纺锤体组装检查点的核心成分,许多研究发现TTK抑制剂可用于恶性肿瘤的治疗,在一些恶性肿瘤中可以与放化疗相结合提高治疗效果,并且TTK可以作为独立的生物标志物提示预后。本文对TTK抑制剂及其与放化疗联合应用于肿瘤治疗和TTK对肿瘤预后预测的研究进展进行综述。

Threonine and tyrosine kinase(TTK)are the core components of the spindle assembly checkpoint.Many studies have found that TTK inhibitors can be used in the treatment of malignant tumors.The combination of chemotherapy and radiotherapy improves the treatment effect,and TTK can be used as an independent biomarker to indicate prognosis.This article reviews the research progress of TTK inhibitors and their combined use with radiotherapy and chemotherapy in tumor therapy and TTK in predicting tumor prognosis.