摘要
目前,骨质疏松症(OP)的防治主要集中于抑制骨吸收,但其局限性已显现。近年文献报道,血管生成与OP关系密切,而且发现血管生成与骨代谢间存在特定的“耦合”关系。血管生成,尤其是H型血管,可能通过影响骨形成、骨吸收及骨重塑进程的方式,在OP发生、发展及防治过程中发挥着重要的调节作用。本文重点梳理血管生成与骨代谢和0P之间的关系,可更全面、系统地认识OP,为其防治研究提供新的思路和理论支撑。
At present,the prevention and treatment of osteoporosis(OP)is mainly focus on the inhibition of bone resorption,and the limitations have now emerged.In recent years,it has been reported that angiogenesis is closely related to OP,and there is a specific coupling relationship between angiogenesis and bone metabolism.Angiogenesis,especially H-type blood vessels,may play an important regulatory role in the occurrence,development,and prevention of OP by influencing bone formation,resorption and remodeling.This article focuses on sorting out the relationship between angiogenesis and bone metabolism as well as OP,in order to understand OP disease more comprehensively and systematically,and provide new ideas and theoretical supports for studies of the prevention and treatment of OP.
作者
齐保玉
魏戌
朱立国
戴建业
孙凯
银河
章轶立
Qi Baoyu;Wei Xu;Zhu Liguo;Dai Jianye;Sun Kai;Yin He;Zhang Yili(Orthopedics Department of Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Beijing Key Laboratory of Orthopedics of Traditional Chinese Medicine,Beijing,100007,China;School of Pharmacy,Lanzhou University,Lanzhou 730020,China;Institute of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《国际内分泌代谢杂志》
2021年第2期128-132,共5页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金(81704102)
中国博士后科学基金(2019M662284)
国家中医药领军人才支持计划——“岐黄学者”计划
中华中医药学会(2017—2019年度)青年人才托举工程项目(CACM-2017-QNRC2-A03)
中国中医科学院“十三五”重点领域科研项目(ZZ10-022)
江西省博士后研究人员择优资助科研项目(2019KY18)。
关键词
骨质疏松症
骨代谢
成骨细胞
破骨细胞
Angiogenesis
Osteoporosis
Bone metabolism
Osteoblast
Osteoclast
