血清omentin-1和vaspin在非酒精性脂肪性肝病患者中的表达及意义

The expression and significance of serum omentin-1 and vaspin in nonalcoholic fatty liver disease

目的探讨脂肪因子网膜蛋白-1(omentin-1)、内脏脂肪组织来源的丝氨酸蛋白酶抑制剂(visceral adipose tissue-derived serine protease inhibitor,vaspin)在非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者中的表达和意义,及其与白细胞介素-6(interleukin-6,IL-6)和C反应蛋白(creactive protein,CRP)的关系。方法138例NAFLD患者(NAFLD组),B超检查证实脂肪肝,129例健康者作为对照组。均记录身高、体质量、腰围(WC),体质指数(BMI),检验血生化,及omentin-1、vaspin、IL-6和CRP水平。结果与对照组相比,NAFLD组的vaspin水平升高,omentin-1水平下降,IL-6、CRP水平增高(均P<0.05)。相关分析:vaspin水平分别与腰围、LDL-C、CRP、IL-6成正比(r值为0.231~0.341,均P<0.05);与HDL-C、omentin-1呈负相关(r值分别为-0.221,-0.246,均P<0.05)。血清omentin-1水平与腰围、CRP、IL-6呈负相关(r值为别-0.238~-0.319,均P<0.05),与HDL-C呈正相关(r=0.326,P<0.05)。Logistic回归分析:omentin-1、vaspin、腰围、CRP、IL-6为患者发生NAFLD的独立相关因素[β值1.471~2.012,OR值(1.021~3.012),95%CI(1.431~4.979),均P<0.05]。结论 NAFLD患者omentin-1、vaspin、IL-6、CRP和健康组不同。Vaspin可能是NAFLD发生的预测因子,而omentin-1可能是预防NAFLD发生的保护性因子。其机制可能与炎症因子有关,具体机制需进一步研究。

Objective To investigate the circulating levels of omentin1,visceral adipose tissue-derived serine protease inhibitor(vaspin)in NAFLD patients and to clarify their relationship with biochemical parameters,interleukin-6(IL-6),and C reactive protein(CRP).Methods One hundred and eight patients with NAFLD(NAFLD group),confirmed fatty liver by B-ultrasound,129 healthy controls as control group.Height,weight,waist circumference,body mass index(BMI),blood biochemistry,serum CRP,IL-6,omentin-1,vaspin and apelin levels were recorded.Results Compared with the control group,the levels of serum vaspin in the NAFLD group were increased,the levels of omentin-1 were decreased,and the levels of IL-6 and CRP were increased.The difference was statistically significant(P<0.05).The vaspin levels were directly proportional to WC,LDL-C,CRP,and IL-6(r values were 0.231 to 0.341,both P<0.05);negatively correlated with HDL-C and omentin-1(r values were-0.221,-0.246,respectively,both P<0.05).Serum omentin-1 levels were negatively correlated with WC,CRP and IL-6(r value was-0.238 to-0.319,both P<0.05),and positively correlated with HDL-C(r=0.326,P<0.05).Logistic regression analysis showed that omentin-1,vaspin,waist circumference,CRP,IL-6 were independent factors related to NAFLD in patients[βvalues were 1.471-2.012,OR(1.021-3.012),95%CI(1.431-4.779),both P< 0.05].Conclusion In patients with NAFLD,levels of omentin-1,vaspin,IL-6,and CRP were different from those in the healthy group.Vaspin may be predictors of NAFLD,and omentin-1 may be a protective factor against the development of NAFLD.Its mechanism may be related to inflammatory factors.The specific mechanism needs further study.