妊娠高血压患者联合给予硫酸镁与拉贝洛尔的效果分析

Analysis of the Effect of Combined Administration of Magnesium Sulfate and Labetalol in Patients with Pregnancy-induced Hypertension

目的妊娠高血压患者联合给予硫酸镁与拉贝洛尔的效果分析。方法纳入2019年7月—2020年2月期间该院收治的108例妊娠高血压患者展开研究分析,结合患者住院床位号的奇偶性以及54例单组区间标准将患者分别归为对照组、试验组;对照组院内治疗方案为硫酸镁单独给药,试验组院内治疗方案为硫酸镁与拉贝洛尔联合给药,以两组患者治疗前后的收缩压、舒张压、血细胞比容、血黏度以及24 h尿蛋白以及不良妊娠发生率为观察指标,对比两种治疗方案的应用价值。结果治疗后试验组的收缩压、舒张压(128.15±9.79)mmHg、(79.83±8.85)mmHg均低于对照组(146.02±14.75)mmHg、(95.75±9.72)mmHg,组间差异有统计学意义(t=7.418、8.900,P<0.05);试验组血细胞比容(32.13±3.71)%、血黏度(2.11±0.23)mPa/s、24 h尿蛋白(1.00±0.22)g均低于对照组(38.49±3.31)%(3.36±0.52)mPa/s、(1.71±0.16)g,组间比较差异有统计学意义(t=9.400、16.155、19.180,P<0.05);试验组不良妊娠发生率(7.41%),低于对照组的22.22%,组间比较差异有统计学意义(χ^(2)=4.696,P<0.05)。结论妊娠高血压患者联合给予硫酸镁与拉贝洛尔,可以改善患者的血压与肾功能,减少患者出现不良妊娠的风险性,对患者的预后有积极意义。

Objective To analyze the effect of combined administration of magnesium sulfate and labetalol in patients with pregnancy-induced hypertension.Methods 108 patients with hypertension during pregnancy in the hospital from July 2019 to February 2020 were enrolled to conduct research and analysis.Combining the parity of the patient's hospital bed number and 54 single-group interval standards,the patients were classified as the control group and the experimental group;the hospital treatment plan of the control group was magnesium sulfate alone,and the hospital treatment plan of the experimental group was magnesium sulfate and labetalol combined administration.The systolic blood pressure,diastolic blood pressure,hematocrit and blood pressure viscosity,24 h urine protein,and incidence of adverse pregnancy of the two groups were measured before and after treatment,to compare the application value of the two treatment options.Results After treatment,the systolic blood pressure and diastolic blood pressure of the test group(128.15±9.79)mmHg,(79.83±8.85)mmHg were lower than those of the control group(146.02±14.75)mmHg,(95.75±9.72)mmHg,and the difference between the groups was statistically significant(t=7.418,8.900,P<0.05);the test group's hematocrit(32.13±3.71)%,blood viscosity(2.11±0.23)mPa/s,24 h urine protein(1.00±0.22)g were all lower than the control group(38.49±3.31)%,(3.36±0.52)mPa/s,(1.71±0.16)g,the difference between the groups was statistically significant(t=9.400,16.155,19.180,P<0.05);the incidence of adverse pregnancy in the test group(7.41%)was lower than that in the control group 22.22% of the total,the difference between the groups was statistically significant(χ^(2)=4.696,P<0.05).Conclusion The combined administration of magnesium sulfate and labetalol in patients with pregnancy-induced hypertension can improve the blood pressure and renal function of the patients,reduce the risk of adverse pregnancy in the patients,and have positive significance for the prognosis of the patients.