丙基硫氧嘧啶治疗妊娠期甲亢的效果与不良反应分析

Analysis of the Effects and Adverse Reactions of Propylthiouracil in the Treatment of Hyperthyroidism during Pregnancy

目的对妊娠期甲亢患者采用丙基硫氧嘧啶治疗的效果及不良反应进行观察和比较。方法选择该院收治的妊娠期甲亢患者108例作为该次研究纳入的研究对象,选取时间段为2019年1—11月,按照随机数字表法将其划分为常规组(没有严格按照医嘱服药或者拒绝服用丙基硫氧嘧啶)和治疗组(严格按照医嘱服用丙基硫氧嘧啶),每组54例。对比两组患者的治疗效果及不良反应。结果治疗后,治疗组的TSH(2.8±0.4)mIU/L、FT3(6.5±1.2)pmol/L、FT4(11.9±2.0)pmol/L均明显优于常规组(1.0±0.3)mIU/L、(12.6±1.3)pmol/L、(23.6±2.4)pmol/L,差异有统计学意义(t=24.429、25.336、27.520,P<0.05);治疗组的不良妊娠结局(3.7%)、明显低于常规组的24.1%,差异有统计学意义(χ^(2)=9.368,P<0.05)。结论对妊娠期甲亢患者采用丙基硫氧嘧啶治疗具有很好的效果,可以有效改善患者的甲状腺功能,而且还可以减少不良妊娠结局率,虽然具有一定的不良反应,但是总体安全性较高。

Objective To observe and compare the effects and adverse reactions of propylthiouracil treatment in patients with hyperthyroidism during pregnancy.Methods 108 patients with hyperthyroidism during pregnancy admitted to the hospital were selected as the research objects included in this study.The selected time period was from January to November 2019,and they were divided into the routine group according to the random number table method(not strictly took the medicine as prescribed by the doctor or refused to take propylthiouracil)and the treatment group(take the propylthiouracil strictly according to the doctor's advice);54 cases in each group.The treatment effects and adverse reactions of the two groups of patients were compared.Results After treatment,the TSH(2.8±0.4)mIU/L,FT3(6.5±1.2)pmol/L,and FT4(11.9±2.0)pmol/L of the treatment group were significantly better than those of the conventional group by(1.0±0.3)mIU/L,(12.6±1.3)pmol/L,(23.6±2.4)pmol/L,the difference was statistically significant(t=24.429,25.336,27.520,P<0.05);adverse pregnancy outcome(3.7%)was significantly lower than the 24.1% of the conventional group,the difference was statistically significant(χ^(2)=9.368,P<0.05).Conclusion The use of propylthiouracil in the treatment of hyperthyroidism during pregnancy has a good effect,can effectively improve the patient's thyroid function,and can also reduce the rate of adverse pregnancy outcomes.Although it has certain adverse reactions,the overall safety is relatively high.