血流变及血栓前标志物在诊断阻塞性睡眠呼吸暂停低通气综合征并发心脑血管血栓栓塞性疾病中的应用价值

Application Value of Hemorheology and Pre-Thrombosis Markers in the Diagnosis of Obstructive Sleep Apnea-HypopneaSyndrome Complicated with Cardio-Cerebrovascular Thromboembolic Diseases

目的探讨血流变及血栓前标志物在诊断阻塞性睡眠呼吸暂停低通气综合征(OSAHS)并发心脑血管血栓栓塞性疾病中的应用价值。方法 78例OSAHS患者按是否并发心脑血管血栓栓塞性疾病分别并发组(n=39)、未并发组(n=39),比较两组的血流变指标、血栓前标志物水平,分析血流变指标与睡眠呼吸参数的相关性。结果并发组的全血粘度、红细胞聚集指数、D-D、 vWF、 AT-Ⅲ均高于未并发组,红细胞电泳时间长于未并发组(P <0.05)。全血粘度、红细胞电泳时间、红细胞聚集指数与AHI指数、 TSaO_2<90呈正相关,而与MinSaO_2呈负相关。结论检测血流变及血栓前标志物有助于诊断OSAHS并发心脑血管血栓栓塞性疾病,对临床诊治有重要作用。

Objective To explore the application value of hemorheology and pre-thrombosis markers in the diagnosis of obstructive sleep apnea-hypopnea syndrome(OSAHS)complicated with cardio-cerebrovascular thromboembolic diseases.Methods 78 cases of OSAHS patients were divied into the complication grouop(n=39)and the non-complication group(n=39)according to the complication of cardio-cerebrovascular thromboembolic diseases.The levels of hemorheology indicators and pre-thrombosis markers were compared between two groups,and the correlations between hemorheology indicators and sleep breathing parameters were analyzed.Results The whole blood viscosity,erythrocyte aggregation index,D-D,vWF and AT-Ⅲin the complication group were higher than those in the non-complication group,and the erythrocyte electrophoresis time was longer than that in the non-complication group(P<0.05).Whole blood viscosity,erythrocyte electrophoresis time and erythrocyte aggregation index were positively correlated with AHI index and TSaO2<90,but negatively correlated with MinSaO2.Conclusions The detection of hemorheology and pre-thrombosis markers is helpful for the diagnosis of OSAHS complicated with cardio-cerebrovascular thromboembolic diseases,which plays an important role in clinical diagnosis and treatment.