阿托伐他汀对冠状动脉无复流作用机制的研究进展

Research Progress in the Mechanism of Atorvastatin on No-reflow of Coronary Artery

冠状动脉无复流是再灌注治疗常见并发症,患者预后会因此受到严重影响。目前多项研究证实阿托伐他汀除具有明显的调整血脂作用外,还对冠状动脉介入治疗术后的心肌血液再灌注具有明显的改善作用,可预防和显著减少无复流现象的发生,改善心肌功能,其作用机制主要有抗炎、改善内皮功能、上调内皮型一氧化氮合酶水平及促进一氧化氮合成和抗凋亡作用等。

Coronary no-reflow is a common complication of reperfusion therapy.The prognosis of patients will be seriously affected.Many studies have proved that statins can not only reduce blood lipid,but also improve myocardial blood perfusion after percutaneous coronary intervention(PCI),prevent and reduce no-reflow phenomenon,and improve cardiac function.The mechanism of action mainly includes anti-inflammation,improving endothelial function,up-regulating endothelial nitric oxide synthase level,promoting nitric oxide synthesis and anti-apoptosis.