雌激素相关受体α在三阴性乳腺癌中的表达和临床意义

Expression and clinical significance of estrogen-related receptorαin triple-negative breast cancer

目的探讨雌激素相关受体α(ERRα)在三阴性乳腺癌(TNBC)中的表达和临床意义,为临床治疗TNBC提供理论支持。方法选取2013年1月-2018年12月天津市津南区咸水沽医院收治的TNBC患者86例为研究对象,免疫组织化学法检测肿瘤组织中ERRα的表达情况,统计分析ERRα表达与临床病理特征及预后的关系。结果86例TNBC患者ERRα阴性表达率为52.32%(45例),阳性表达率为47.67%(41例)。ERRα与TNM分期、淋巴结转移及脉管癌栓有关,差异有统计学意义(均P<0.05),与年龄、肿瘤直径及组织学分级无关,差异无统计学意义(均P>0.05)。ERRα表达阴性患者无复发生存率(DFS)显著高于ERRα表达阳性患者,差异有统计学意义(P<0.05),但两者5年总体生存率(OS)差异无统计学意义(P>0.05)。Cox比例风险回归模型分析结果显示,TNM分期、组织学分级、淋巴结转移、脉管癌栓及ERRα表达是TNBC患者的独立预后因素。结论ERRα影响TNBC的复发和转移,其高表达的TNBC临床预后差。

Objective To explore the expression and clinical significance of estrogen-related receptorα(ERRα)in triple-negative breast cancer(TNBC),provide theoretical support for clinical treatment of TNBC.Methods From January 2013 to December 2018,86 patients with TNBC were selected from Xianshuigu Hospital of Jinnan District,immunohistochemistry was used to detect the expression of ERRαin tumor tissue,the relationships between ERRαexpression and clinicopathological features,prognosis were analyzed statistically.Results The negative expression rate and positive expression rate of ERRαin 86 patients with TNBC were 52.32%(45 cases)and47.67%(41 cases),respectively.ERRαwas associated with TNM stage,lymph node metastasis,and vascular tumor thrombus(P<0.05);ERRαwas not associated with age,tumor diameter,and histological grade(P>0.05).DFS of patients with negative ERRαexpression was statistically significantly higher than that of patients with positive ERRαexpression(P<0.05),but there was no statistically significant difference in five-year overall survival rate between the two groups(P>0.05).Cox proportional hazards regression model analysis showed that TNM stage,histological grade,lymph node metastasis,vascular tumor thrombus,and ERRαexpression were independent prognostic factors in patients with TNBC.Conclusion ERRαaffects recurrence and metastasis of TNBC,clinical prognosis is poor in TNBC patients with high ERRαexpression.