摘要
以2-氯环己酮为原料,经亲核磺化、氯化和胺化3步反应合成了环己磺菌胺,总收率55.6%。中间体2-氧代环己基磺酸钠和环己磺菌胺的结构经核磁共振氢谱和碳谱确证。该工艺方法操作简单,反应条件温和。
Chesulfamide was obtained with a total yield of 55.6%through sequential nucleophilic sulfonylation,chloronation and amination of 2-chlorocyclohexanone.The structures of sodium 2-oxocyclohexane-1-sulfonate as a key intermediate and chesulamide were confirmed by IR,^(1)H and ^(13)C NMR spectra.This new process has advantages including easy operation and mild conditions.
作者
冯姝尧
江晓敏
颜芊
李江胜
FENG Shu-yao;JIANG Xiao-min;YAN Qian;LI Jiang-sheng(School of Chemistry and Food Engineering,Changsha University of Science&Technology,Changsha 410117,China)
出处
《精细化工中间体》
CAS
2021年第1期5-7,共3页
Fine Chemical Intermediates
基金
国家重点研发计划资助项目(2017YFB0307200)
国家级大学生创新创业训练计划项目(202010536017)。
关键词
环己磺菌胺
2-氯环己酮
磺化
胺化
chesulfamide
2-chlorocyclohexanone
sulfonylation
amination
