摘要
With the rapid improvements in nanomaterials and imaging technology,great progresses have been made in diagnosis and treatment of diseases during the pastdecades.Fe_(3)O_(4) magnetic nanoparticles(MNPs)with good biocompatibility and super-paramagnetic property are usually used as contrast agent for diagnosis of diseases inmagnetic resonance imaging(MRI).Currently,the combination of multiple imagingtechnologies has been considered as new tendency in diagnosis and treatment ofdiseases,which could enhance the accuracy and reliability of disease diagnosis andprovide new strategies for disease treatment.Therefore,novel contrast agents used formultifunctional imaging are urgently needed.Fe_(3)O_(4) MNPs are believed to be a potentialcandidate for construction of multifunctional platform in diagnosis and treatment ofdiseases.In recent years,there are a plethora of studies concerning the construction ofmultifunctional platform presented based on Fe_(3)O_(4) MNPs.In this review,we introducefabrication methods and modification strategies of Fe_(3)O_(4) MNPs,expecting greatimprovements for diagnosis and treatment of diseases in the future.
基金
supported by the National Natural Science Foundation of China(Grant Nos.11502158,11632013 and 11802197)
The support of the Shanxi Provincial Key Research and Development Project,China(Grant Nos.201803D421060,201903D421064 and 201803D421076)
the Natural Science Foundation of Shanxi Province,China(201901D111078 and 201901D111077)
the Shanxi ScholarshipCouncil of China(No.HGKY2019037)are also acknowledged withgratitude.
