摘要
介孔材料是一种孔径介于2~50 nm之间的新型多孔固体材料,由于其具有较大的比表面积、优异的化学和热稳定性、孔径可调、密度低等特点而受到广泛关注,已成为一种极具发展前途的药物传递载体系统(DDSs)。然而,基于介孔材料的DDSs在临床应用还面临一些挑战。为了系统总结介孔材料在药物传递中的研究进展以及更加高效地开发基于介孔材料的药物载体,作者将介孔材料分别按照空间的分布有序性和化学组成进行分类总结,根据空间分布是否有序将介孔材料分为有序介孔材料和无序介孔材料;按化学组成分为硅基介孔材料和非硅基介孔材料。作者介绍了介孔材料常用合成方法,包括溶胶-凝胶法、水热合成法、微波合成法、相转变法和沉淀法等,其中溶胶凝胶法和水热合成法最为常用;同时也介绍了典型的、研究最广泛的介孔材料在化学药物和生物技术药物传递中的研究进展以及介孔材料种类、孔径大小、表面官能团和物理状态对其药物传递效率的影响。作者在文章最后讨论了基于介孔材料的DDSs存在的问题和未来的发展方向。
Mesoporous material is a new type of porous solid material with pore size between 2-50 nm.Because of its large specific surface area,excellent chemical and thermal stability,adjustable pore size and low density,mesoporous material has become a promising drug delivery system(DDSs).However,there are still some challenges in clinical application of mesoporous material-based DDSs.In order to systematically summarize the research progress of mesoporous materials in drug delivery and to develop drug carriers based on mesoporous materials more efficiently,the authors classified mesoporous materials according to their spatial distribution order and chemical composition,which were divided into ordered mesoporous materials and disordered mesoporous materials according to their spatial distribution,and silicon-based mesoporous materials and non-silicon-based mesoporous materials according to their chemical composition.Then,the common synthesis methods were introduced,including sol-gel method,hydrothermal synthesis method,microwave synthesis method,phase transformation method and precipitation method,among which sol-gel method and hydrothermal synthesis method were the most commonly used.At the same time,the research progress of typical and most widely studied mesoporous materials in chemical and biotechnology drug delivery and the effects of the type,pore size,surface functional groups and physical state of mesoporous materials on drug delivery efficiency were also introduced.Finally,the existing problems and future development direction of DDSs based on mesoporous materials were discussed in this paper.
作者
胡丹蕾
杨钮钮
张傲雪
陈冬梅
张景齐
谢书宇
HU Danlei;YANG Niuniu;ZHANG Aoxue;CHEN Dongmei;ZHANG Jingqi;XIE Shuyu(Ministry of Agriculture and Rural Affairs Livestock Product Quality and Safety Risk Assessment Laboratory,National Veterinary Drug Safety Evaluation Laboratory,National Reference Laboratory for Veterinary Drug Residues(HZAU),Huazhong Agricultural University,Wuhan 430070,China;Xiagezhuang Institute of Animal Health Administration,Pinggu,Beijing,Beijing 101200,China)
出处
《中国畜牧兽医》
CAS
北大核心
2021年第4期1498-1505,共8页
China Animal Husbandry & Veterinary Medicine
基金
国家重点研发计划专项“畜禽重要病原耐药性检测与控制技术研究”(2016YFD0501309)。
