中药塌渍联合左氧氟沙星、坦索罗辛治疗慢性前列腺炎的临床疗效分析

Clinical analysis of traditional Chinese medicine collapsing stains combined with levofloxacin and tamsulosin in the treatment of chronic prostatitis

目的研究中药塌渍联合左氧氟沙星、坦索罗辛治疗慢性前列腺炎的临床疗效。方法将2018年3月至2020年3月辽宁中医药大学附属第二医院治疗的90例慢性前列腺炎患者,随机分为观察组及对照组,观察组应用中药塌渍联合左氧氟沙星、坦索罗辛治疗,对照组患者应用左氧氟沙星、坦索罗辛治疗,两组患者均治疗4周,比较两组患者慢性前列腺炎症状评分(NIH-CPSI)、国际勃起功能指数(IIEF-5)、焦虑自评量表(SAS)积分、中医症状评分、前列腺液(EPS)中白细胞计数(WBC)以及肿瘤坏死因子(TNF-α)水平情况。结果干预治疗4周,对照组总有效率为71.1%,观察组总有效率为91.1%,观察组疗效明显优于对照组(P<0.05)。治疗后,两组NIH-CPSI评分均较治疗前明显降低(P<0.05),与对照组相比,观察组各项评分均显著降低(P<0.05)。治疗后,两组患者IIEF-5评分均较治疗前增高(P<0.05),与对照组相比,观察组的指数高于对照组(P<0.05)。治疗后,两组患者SAS评分均较治疗前降低(P<0.05);且组间比较,差异有统计学意义(P<0.05)。治疗后,两组中医症状的总积分、主症积分、次症积分较治疗前降低(P<0.05),且观察组总积分和主症积分均低于对照组(P<0.05)。治疗后,两组患者EPS中白细胞计数及TNF-α水平均显著降低(P<0.05),且组间比较差异有统计学意义(P<0.05)。结论中药塌渍联合左氧氟沙星、坦索罗辛治疗慢性前列腺炎临床疗效可靠,值得推广。

Objective To study the clinical effect of traditional Chinese medicine(TCM)collapsing stains combined with levofloxacin and tamsulosin in the treatment of chronic prostatitis.Methods From March 2018 to March 2020,90 patients with chronic prostatitis were treated in the Second Hospital of Lioaning University of Chinese Medicine,and they were randomly divided into the observation group and the control group.Patients in the observation group were treated with traditional Chinese medicine collapsing stains combined with levofloxacin and tamsulosin,and patients in the control group were treated with levofloxacin and tamsulosin.Patients in the two groups both were treated for 4 weeks.The chronic prostatitis symptom score(NIH-CPSI),International erectile function index(IIEF-5),self-rating anxiety scale(SAS)scores,TCM symptom scores,white blood cell(WBC)count and tumor necrosis factor-α(TNF-α)levels in prostatic fluid were compared between the two groups.Results The total effective rate of the control group and the observation group was 71.1%and 91.1%,respectively,after 4 weeks of treatments(P<0.05).The NIH-CPSI scores of the two groups were significantly lower after treatment(P<0.05),and all the scores of the observation group were significantly lower than those of the control group(P<0.05).The IIEF-5 score of the two groups was higher after treatment(P<0.05),and the index of the observation group was higher than that of the control group(P<0.05).The SAS scores of the two groups were lower after treatment,and there was significant difference between the two groups(P<0.05).The total score,major symptom score and minor symptom score of TCM symptoms in the two groups were lower after treatment(P<0.05),and the total score and major symptom score in the observation group were lower than those of the control group(P<0.05).After treatment,the WBC count and TNF-αlevel in EPS of the two groups were significantly reduced(P<0.05),and the difference between the two groups was significant(P<0.05).Conclusion The clinical effect of TCM collapsing stains combined with levofloxacin and tamsulosin is reliable,which is worthy of promotion in the treatment of chronic prostatitis.