摘要
本文报道一例抗富亮氨酸胶质瘤失活1蛋白(LGI1)抗体脑炎,患者为中年男性,临床表现主要为快速进展的认知功能障碍和顽固低钠血症,颅脑MRI示双侧海马高信号,血清和脑脊液抗LGI1抗体均为阳性,诊断为抗LGI1抗体脑炎,给予糖皮质激素免疫治疗后认知功能障碍明显缓解。本文分析抗LGI1抗体脑炎的临床特点,并复习相关文献,以警惕中年突发认知功能障碍的脑炎患者,需尽快行血液及脑脊液自身免疫性脑炎抗体标志物检测,早期积极免疫治疗以便控制疾病进展及改善预后。
This article reported a case of anti-leucine-rich glioma inactivation 1 protein(LGI1)antibody encephalitis.The patient was a middle-aged male,his clinical manifestations mainly were rapidly progressing cognitive dysfunction and intractable hyponatremia.,brain MRIshowed hyperintensity in bilateral hippocampal,anti-LGI1 antibody of serum and cerebrospinal fluidwere both positive,then the diagnosis was anti-LGI1 antibody encephalitis.His cognitive dysfunction was significantly relieved after administration of glucocorticoid immunotherapy.This article analyzed the clinical characteristics of anti-LGI1 antibody encephalitis,and reviews related literature to alert middle-aged patients with sudden cognitive impairment.It was necessary to detect autoimmune encephalitis antibody markers in blood and cerebrospinal fluid,and actively immunize earlytreatment to control disease progression and improve prognosis.
作者
郭启雯
邱国真
王音
许春燕
陈淳淳
林燕维
孟雪娅
朱飞奇
GUO Qi-wen;QIU Guo-zhen;WANG Yin;XU Chun-yan;CHEN Chun-chun;LIN Yan-wei;MENG Xue-ya;ZHU Fei-qi(Luohu District People's Hospital,Shenzhen,Guangdong 518000,China;Geriatric Hospital of Luohu District People's Hospital,Shenzhen,Guangdong 518000,China)
出处
《阿尔茨海默病及相关病杂志》
2021年第1期56-59,共4页
Chinese Journal of Alzheimer's Disease and Related Disorders
基金
深圳市罗湖区人民医院神经内科深圳市三名工程“瑞典卡洛琳斯卡医学院NVS系Bengt Winblad阿尔茨海默病团队”,项目编号:SZSM201801014。
