脑苷肌肽联合奥拉西坦治疗急性脑出血的疗效及对血清SF及SAA水平的影响

Effect of cattle encephalon glycoside and ignotin combined with oxiracetam in treatment of acute cerebral hemorrhage and its effect on serum SF and SAA levels

目的探讨脑苷肌肽联合奥拉西坦治疗急性脑出血的临床疗效,及其对血清铁蛋白(SF)、血清淀粉样蛋白A(SAA)水平的影响。方法选取2018年1月—2019年12月在上海中医药大学附属龙华医院接受治疗的148例急性脑出血患者作为研究对象,按照治疗方案将患者分为对照组和观察组,每组各74例。对照组静脉滴注奥拉西坦注射液,5 g奥拉西坦注射液加入到250 mL生理盐水中静滴,1次/d。观察组在对照组治疗基础上静脉滴注脑苷肌肽注射液,20 mL加入250 mL生理盐水中静滴,1次/d。两组均连续给药2周。观察两组患者的临床疗效,同时比较两组患者的脑血肿量、脑水肿量、美国国立卫生研究院卒中量表评分(NIHSS)、Barthel指数(BI)、改良Rankin量表评分(mRS)、血清白细胞介素(IL)-6、IL-10、SF及SAA水平。结果治疗后,观察组为总有效率为89.19%,显著高于对照组的75.68%(P<0.05)。治疗后,两组患者脑血肿量和脑水肿量均显著降低(P<0.05),且观察组脑血肿量和脑水肿量均显著低于对照组(P<0.05)。治疗后,两组NIHSS、mRS评分显著降低,BI评分显著增加(P<0.05);且观察组NIHSS、mRS评分显著低于对照组,BI评分显著高于对照组(P<0.05)。治疗后,两组血清IL-6、SF及SAA水平均显著降低,IL-10水平显著增加(P<0.05);且观察组血清IL-6、SF及SAA水平显著低于对照组,IL-10水平显著高于对照组(P<0.05)。结论奥拉西坦联合脑苷肌肽对急性脑出血患者治疗效果较好,能够显著降低血清SF及SAA水平,减轻炎症反应,保护和修复神经损伤。

Objective To investigate the clinical efficacy of cattle encephalon glycoside and ignotin combined with oxiracetam in treatment of acute cerebral hemorrhage, and its effect on SF and SAA levels. Methods A total of 148 patients with acute cerebral hemorrhage who received treatment in Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2018 to December 2019 were selected as the research subjects. According to the treatment plan, the patients were divided into control group and observation group, with 74 patients in each group. Patients in the control group were intravenously injected with Oxiracetam Injection, 5 g of Oxiracetam Injection was added into 250 mL normal saline, once daily. Patients in the the observation group was intravenously injected with Cattle Encephalon Glycoside and Ignotin Injection on the basis of the control group, 20 mL added into 250 mL normal saline, once daily. Both groups were given continuous medication for 2 weeks. After treatment, the clinical efficacy of two groups was observed, and hematoma volume, brain edema volume, NIHSS score, BI, MRS,the levels of serum IL-6, IL-10, SF and SAA were compared between two groups. Results After treatment, the total effective rate of observation group was 89.19%, which was significantly higher than 75.68% of control group(P < 0.05). After treatment, the amount of cerebral hematoma and brain edema in two groups were significantly decreased(P < 0.05), and the amount of cerebral hematoma and brain edema in the observation group were significantly lower than those in the control group(P < 0.05). After treatment,NIHSS and MRS scores were significantly decreased, while BI scores were significantly increased(P < 0.05). The NIHSS and MRS scores of the observation group were significantly lower than those of the control group, but the BI scores of the observation group were significantly higher than those of the control group(P < 0.05). After treatment, the levels of serum IL-6, SF and SAA in two groups were significantly decreased, while the level of IL-10 was significantly increased(P < 0.05). The levels of serum IL-6, SF and SAA in observation group were significantly lower than those in control group, and the level of IL-10 was significantly higher than that in control group(P < 0.05). Conclusion Cattle encephalon glycoside and ignotin combined with oxiracetam has good therapeutic effect on patients with acute intracerebral hemorrhage, which can significantly reduce serum SF and SAA levels, reduce inflammatory response, and protect and repair nerve damage.