黄连多糖药理作用研究进展

Research progress on pharmacological effects of Coptis Chinensis polysaccharide

黄连多糖是毛茛科植物黄连、三角叶黄连和云连的药效成分之一,具有抗氧化、降血糖、减轻炎症反应和神经保护等广泛的药理作用。其抗氧化可能是通过提高机体抗氧化酶来发挥作用;其降血糖作用机制较多,包括抑制α-淀粉酶、提高胰岛素敏感性和促进葡萄糖摄取;其抗炎作用可能与活化巨噬细胞和抑制炎症反应酪氨酸激酶2/信号转导和转录激活因子3(JAK2/STAT3)信号通路中p-JAK2、p-STAT3的表达有关;可能通过抑制氨基末端激酶(JNK)介导的鼠嗜铬神经瘤细胞(PC12)凋亡信号通路来发挥神经保护作用。对近年来有关黄连多糖的药理作用等文献进行综述,为进一步研究和应用提供参考。

Coptis Chinensis polysaccharide is one of the effective components of Coptis chinensis Franch., C. deltoidea C.Y.Cheng et Hsiao. and C. teeta Wall. in the Ranunculaceae family. It has a wide range of pharmacological effects such as antioxidant,hypoglycemic, anti-inflammatory and neuroprotective effects. Relevant studies have found that its antioxidant may be exerted by increasing the body’s antioxidant enzymes;its hypoglycemic has many mechanisms, such as: inhibiting α-amylase, improving insulin sensitivity and promoting glucose uptake;its anti-inflammatory effect may be related to activation Macrophages are related to the expression of p-JAK2 and p-STAT3 in the tyrosine kinase 2/signal transduction and transcription activator 3(JAK2/STAT3)signaling pathway that inhibits inflammation. For neuroprotection, studies have found that CCP may play a role by inhibiting the JNK-mediated apoptosis signaling pathway in mouse pheochromocytoma cells(PC12). This article reviewed studies on the extraction and purification, monosaccharide composition analysis, and pharmacological effects of Coptis Chinensis polysaccharide in recent years, and provided a perspective on further research and application of it.