血清SCC-Ag、CYFRA21-1、NSE、CEA、CA125、CA199水平在非小细胞肺癌诊治中的价值

Value of serum SCC-Ag,CYFRA21-1,NSE,CEA,CA125,CA199 levels in the diagnosis and treatment of non-small cell lung cancer

目的研究血清鳞状细胞癌抗原(SCC-Ag)、细胞角蛋白19(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)水平在非小细胞肺癌诊治中的价值。方法选取80例非小细胞肺癌患者(观察组)和80名健康体检者(对照组)作为研究对象,检测并比较两组的SCC-Ag、CYFRA21-1、NSE、CEA、CA125、CA199水平,分析其联合诊断的价值。结果观察组的SCC-Ag、CYFRA21-1、NSE、CEA、CA125、CA199水平均高于对照组(P<0.05)。观察组中腺癌患者和鳞癌患者的SCC-Ag、CYFRA21-1、NSE、CEA、CA199水平有显著差异(P<0.05)。SCC-Ag、CYFRA21-1、NSE、CEA、CA125、CA199联合诊断的阳性率高于单一诊断(P<0.05)。治疗后,观察组的SCC-Ag、CYFRA21-1、NSE、CEA、CA125、CA199水平均低于治疗前(P<0.05)。结论SCC-Ag、CYFRA21-1、NSE、CEA、CA125、CA199水平联合检测在非小细胞肺癌诊治中的应用价值显著,能早期明确疾病,为患者后期治疗提供依据。

Objective To study the value of serum squamous cell carcinoma antigen(SCC-Ag),cytokeratin 19(CYFRA21-1),neuron-specific enolase(NSE),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 199(CA199)levels in the diagnosis and treatment of non-small cell lung cancer.Methods Eighty patients with non-small cell lung cancer(observation group)and 80 healthy people(control group)were selected as the research objects.The levels of SCC-Ag,CYFRA21-1,NSE,CEA,CA125 and CA199 in the two groups were detected and compared,and the value of their combined diagnosis was analyzed.Results The levels of SCC-Ag,CYFRA21-1,NSE,CEA,CA125 and CA199 in the observation group were higher than those in the control group(P<0.05).There were significant differences in the levels of SCC-Ag,CYFRA21-1,NSE,CEA,CA125 and CA199 between adenocarcinoma patients and squamous cell carcinoma patients in the observation group(P<0.05).The positive rate of combined diagnosis of SCC-Ag,CYFRA21-1,NSE,CEA,CA125,CA199 were higher than those of single diagnosis(P<0.05).After treatment,the levels of SCC-Ag,CYFRA21-1,NSE,CEA,CA125 and CA199 in the observation group were lower than those before treatment(P<0.05).Conclusion The combined detection of SCC-Ag,CYFRA21-1,NSE,CEA,CA125 and CA199 levels has significant application value in the diagnosis and treatment of non-small cell lung cancer,which can identify the disease in the early stage and provide basis for the later treatment of patients.