不同手术时机下新生儿坏死性小肠结肠炎的效果及对预后的影响

Effect of different operation timing on neonatal necrotizing enterocolitis and its influence on prognosis

目的探讨不同手术时机下新生儿坏死性小肠结肠炎的效果及对预后的影响。方法选取我院2016年2月至2020年2月收治的64例坏死性小肠结肠炎新生儿作为研究对象,根据不同手术时机将其分为早期组(确诊至手术时间≤7 d)与晚期组(确诊至手术时间>7 d),各32例。早期组行早期手术治疗,晚期组行晚期手术治疗。比较两组的PCT、hs-CRP、IL-6水平、预后情况及手术效果。结果手术前、手术后、术后3 d,晚期组的PCT、hs-CRP、IL-6水平均高于早期组(P<0.05)。早期组的术后住院天数短于晚期组,术后并发症总发生率低于晚期组(P<0.05)。早期组的手术优良率高于晚期组(P<0.05)。结论早期进行新生儿坏死性小肠结肠炎手术可降低患儿PCT、hs-CRP、IL-6水平及术后并发症总发生率,提高手术优良率,值得临床推广应用。

Objective To explore the effect of different operation timing on neonatal necrotizing enterocolitis and its influence on prognosis.Methods A total of 64 neonates with necrotizing enterocolitis admitted in our hospital from February 2016 to February 2020 were selected as the research objects and divided into early group(time from diagnosis to operation≤7 d)and late group(time from diagnosis to operation>7 d)according to different operation timing,with 32 cases in each group.The early group was treated with early operation,and the late group was treated with late operation.The levels of PCT,hs-CRP,IL-6,prognosis and surgical effect were compared between the two groups.Results Before operation,aftetr operation and 3 d after operation,PCT,hs-CRP and IL-6 levels in the late group were higher than those in the early group(P<0.05).The postoperative hospital stay in the early group was shorter than that in the late group,and the total incidence of postoperative complications was lower than that in the late group(P<0.05).The excellent and good rate of surgery in the early group was higher than that in the late group(P<0.05).Conclusion Early neonatal necrotizing enterocolitis surgery can reduce the PCT,hs-CRP,IL-6 levels and the total incidence of postoperative complications,improve the excellent and good rate of surgery,which is worthy of clinical promotion and application.