老年晚期消化道肿瘤患者行卡培他滨单药连用方案治疗的临床探讨

Clinical Study of Capecitabine Single-drug Combination Regimen in the Treatment of Elderly Patients with Advanced Digestive Tract Tumors

目的探究老年晚期消化道肿瘤患者行卡培他滨单药连用方案的疗效。方法选择该院2017年8月—2019年2月收治的老年晚期消化道肿瘤患者54例为研究对象,按数字随机分组法将其分为研究组和对照组,每组27例。研究组患者每日使用卡倍他滨2000.0 mg/m^(2),连续用药21 d,4周重复;对照组使用卡倍他滨2500.0 mg/m^(2),连续用药14 d,3周重复。两组患者用药2个周期后,分别就两组患者的疗效和不良反应发生情况进行对比。结果研究组患者的治疗有效率为66.67%,高于对照组33.33%,差异有统计学意义(χ^(2)=6.555,P<0.05);不良反应发生率方面,研究组患者色素沉着为81.5%、手足综合征发生率为74.1%,明显低于对照组100.0%、100.0%,差异有统计学意义(χ^(2)=4.688、5.909,P<0.05);其他不良反应,恶心呕吐(70.4%)、口腔炎(59.3%)与对照组的63.0%与66.7%对比,两组差异无统计学意义(χ^(2)=0.841、0.318,P>0.05)。结论与传统14 d治疗方案相比,合理减少药物剂量,延长用药时间,可以在保障疗效的基础上,减少患者不良反应的发生,有利于提高患者的耐受性,值得临床推广和使用。

Objective To explore the curative effect of capecitabine monotherapy in elderly patients with advanced gastrointestinal tumors.Methods 54 elderly patients with advanced gastrointestinal tumors admitted to the hospital from August 2017 to February 2019 were selected as the research objects,and they were divided into a study group and a control group according to the number random grouping method,with 27 cases in each group.The patients in the study group received cabetabine 2000.0 mg/m^(2) daily for 21 days,repeated for 4 weeks;the control group received cabcitabine 2500.0 mg/m^(2) for 14 consecutive days,repeated for 3 weeks.After 2 cycles of medication between the two groups of patients,the efficacy and adverse reactions of the two groups of patients were compared.Results The effective rate of treatment in the study group was 66.67%,which was higher than 33.33% in the control group,and the difference was statistically significant(χ^(2)=6.555,P<0.05).In terms of the incidence of adverse reactions,the incidence of pigmentation in the study group was 81.5%,hands and feet syndrome was 74.1%,which was significantly lower than 100.0% and 100.0% in the control group,and the difference was statistically significant(χ^(2)=4.688,5.909,P<0.05);other adverse reactions,nausea and vomiting(70.4%),stomatitis(59.3%).compared with 63.0% and 66.7% of the control group,the difference of the two groups was not statistically significant(χ^(2)=0.841,0.318,P>0.05).Conclusion Compared with the traditional 14-day treatment plan,rationally reducing the drug dose and prolonging the medication time can reduce the incidence of patient adverse reactions on the basis of ensuring the efficacy,which is beneficial to improve the tolerance of patients and is worthy of clinical promotion and use.