奥美拉唑、替硝唑和克拉霉素联合治疗胃炎患儿的效果

The Effect of Omeprazole,Tinidazole and Clarithromycin in the Treatment of Children with Gastritis

目的对胃炎患儿采用奥美拉唑、替硝唑和克拉霉素联合治疗的效果进行研究。方法选择该院2019年1月—2020年1月收治的胃炎患儿68例作为该次研究纳入的研究对象,按照随机数字表法为依据将其划分为常规组(34例,奥美拉唑、阿莫西林及甲硝唑等联合治疗)和治疗组(34例,奥美拉唑、替硝唑和克拉霉素联合治疗),对比两组患儿的临床疗效和不良反应。结果治疗组的总有效率(97.1%)与常规组(73.5%)比较明显更高,比较差异有统计学意义(χ^(2)=7.503,P<0.05);治疗组的纳差改善时间(31.6±9.5)h、上腹痛改善时间(11.7±3.2)h、呕吐改善时间(7.8±1.2)h与常规组(50.3±8.7)、(22.8±3.8)、(13.2±2.5)h比较明显更少,差异有统计学意义(t=8.465、13.028、11.354,P<0.05);治疗组的不良反应率(5.8%)与常规组(23.5%)比较明显更低,差异有统计学意义(χ^(2)=4.221,P<0.05)。结论针对胃炎患儿采用奥美拉唑、替硝唑和克拉霉素联合治疗具有很好的效果,可以有效改善患儿的临床症状,而且不良反应少,具有很高的安全性。

Objective To study the effect of combined treatment of omeprazole,tinidazole and clarithromycin in children with gastritis.Methods A total of 68 children with gastritis admitted to the hospital from January 2019 to January 2020 were selected as the study subjects included in this study,and they were divided into the routine group(34 cases,omeprazole,omeprazole,Combination therapy of amoxicillin and metronidazole)and the treatment group(34 cases,combined therapy of omeprazole,tinidazole and clarithromycin),compared the clinical efficacy and adverse reactions of the two groups of children.Results The total effective rate(97.1%)of the treatment group was significantly higher than that of the conventional group(73.5%),and the difference was statistically significant(χ^(2)=7.503,P<0.05);the treatment group's anorexia improvement time(31.6±9.5)h.The improvement time of upper abdominal pain(11.7±3.2)h and the improvement time of vomiting(7.8±1.2)h were significantly less than those of the conventional group(50.3±8.7)h,(22.8±3.8)h,and(13.2±2.5)h.The difference was statistically significant(t=8.465,13.028,11.354,P<0.05);the adverse reaction rate of the treatment group(5.8%)was significantly lower than that of the conventional group(23.5%),and the difference was statistically significant(χ^(2)=4.221,P<0.05).Conclusion The combined treatment of omeprazole,tinidazole and clarithromycin for children with gastritis has a good effect.It can effectively improve the children's clinical symptoms,with few adverse reactions and high safety.