PCT、S100B、NSE及MRI在儿童感染性颅内高压的作用研究进展

Research Progress on the Role of PCT,S100B,NSE and MRI in Children with Infectious Intracranial Hypertension

感染性颅内高压(IICH)是由多种感染性疾病包括颅内及颅外感染引起的颅内压增高(ICH)产生的临床症状的总称,是儿童颅内压增高的主要临床类型,也是小儿较为常见的感染疾病的严重并发症,严重者可并发脑疝而危及生命,是神经系统的急危重症之一,具有发病急、进展快、致死率和致残率高等特点。早期发现、及时处理是挽救患儿生命及减少神经系统后遗症的关键。该文介绍了降钙素原(PCT)、血浆钙连接蛋白B(S100B),神经元特异性烯醇化酶(NSE)和磁共振成像(MRI)在儿童IICH诊断及治疗中的应用新进展,为临床诊疗提供帮助。

Infectious intracranial hypertension(IICH)is a general term for the clinical symptoms of increased intracranial pressure(ICH)caused by a variety of infectious diseases,including intracranial and extracranial infections.It is the main clinical type of intracranial pressure increase in children and also a common complication of serious infectious diseases in children.In severe cases,it can be complicated by brain herniation and life-threatening.It is one of the critical illnesses of the nervous system.It has the characteristics of rapid onset,rapid progress,high mortality and disability.Early detection and timely treatment are the keys to saving the lives of children and reducing the sequelae of the nervous system.This article introduces new advances in the application of procalcitonin(PCT),plasma calnexin B(S100B),neuron-specific enolase(NSE)and magnetic resonance imaging(MRI)in the diagnosis and treatment of children's IICH,which provides help for clinical diagnosis and treatment.