胰岛素+达格列净治疗2型糖尿病的效果和对患者血糖的影响探讨

Study on the Effect of Insulin+Dapagliflozin in the Treatment of Type 2 Diabetes and Its Influence on Patients'Blood Glucose

目的探讨胰岛素+达格列净治疗2型糖尿病的效果和对患者血糖的影响。方法将该院2018年10月—2020年6月期间治疗2型糖尿病患者88例作为研究对象,所有患者均采用常规降糖药物胰岛素进行治疗,根据是否联合应用达格列净药物分为两组,每组44例,对照组给予常规降糖药物进行治疗,试验组则在对照组基础上联合应用达格列净片,所有患者均连续治疗4周,观察两组患者治疗前后血脂各项指标变化(TC、TG、LDL-C)以及各组患者空腹血糖、餐后2 h血糖变化,同时分析患者日常生活质量以及不良反应发生情况。结果试验组患者空腹血糖、餐后血糖水平明显较对照组降低,差异有统计学意义(P<0.05),试验组患者治疗前血脂各项指标差异无统计学意义(P>0.05),经不同药物治疗后,试验组患者各项血脂指标较对照组明显改善,差异有统计学意义(P<0.05)。结论采用胰岛素+达格列净治疗效果良好,不仅有效控制血糖在正常波动范围,同时降低血脂,调节机体代谢,安全性和可行性高,提高患者日常生活质量。

Objective To investigate the effect of insulin+dapagliflozin in the treatment of type 2 diabetes and its influence on patients'blood sugar.Methods 88 patients with type 2 diabetes were treated in the hospital from October 2018 to June 2020 as the research objects.All patients were treated with the conventional hypoglycemic drug insulin,and were divided into two groups according to whether they were combined with dapagliflozin,44 cases in each group,the control group was treated with conventional hypoglycemic drugs.The test group was combined with dapagliflozin tablets on the basis of the control group.All patients were treated for 4 consecutive weeks.The changes of blood lipid indexes(TC,TG,LDL-C)and fasting blood glucose of each group were observed before and after treatment,the blood glucose change 2 h after meal,and analyzed the patient's daily life quality and the occurrence of adverse reactions at the same time.Results The fasting blood glucose and postprandial blood glucose levels of the test group were significantly lower than those of the control group.The difference was statistically significant(P<0.05).There was no statistically significant difference in the blood lipid indexes of the test group before treatment(P>0.05).After treatment with different drugs,the blood lipid indexes of the patients in the test group were significantly improved compared with the control group,the difference was statistically significant(P<0.05).Conclusion The study of insulin+dapagliflozin has a good therapeutic effect.It not only effectively controls blood glucose in the normal fluctuation range,but also reduces blood lipids,regulates body metabolism,has high safety and feasibility,and improves the quality of patients'daily life.