结肠透析治疗对急性胰腺炎患者临床症状、血清指标水平及APACHEⅡ评分的影响

Effect of Colon Dialysis Treatment on Clinical Symptoms,Serum Index Levels and APACHEⅡScore in Patients with Acute Pancreatitis

目的分析结肠透析治疗对急性胰腺炎患者临床症状、血清指标水平及APACHEⅡ评分的影响。方法回顾性收集2017年4月—2019年5月该院收治的116例急性胰腺炎患者的临床资料,根据治疗方法不同分为对照组(使用常规治疗)48例和研究组(结肠透析治疗)68例。对比两组患者治疗后临床症状恢复时间以及治疗前后血清指标水平、APACHEⅡ评分以及并发症情况。结果研究组腹胀、腹痛、肠胃功能及血清淀粉酶恢复正常时间均明显短于对照组,差异有统计学意义(P<0.05);治疗前两组患者血清指标水平、APACHEⅡ评分比较差异无统计学意义(P>0.05),治疗后两组TNF-α、IL-6、IL-8、APACHEⅡ评分均呈明显下降趋势,而研究组下降幅度更明显,差异有统计学意义(P<0.05)。对照组不良反应总发生率为8.33%(4/48),研究组为5.88%(4/68),比较差异无统计学意义(χ^(2)=0.263,P=0.608)。结论结肠透析治疗可加快急性胰腺炎患者病情恢复,改善患者血清指标水平以及APACHEⅡ评分,为有效的辅助治疗方法。

Objective To analyze the effect of colon dialysis treatment on the clinical symptoms,serum index levels and APACHEⅡscore in patients with acute pancreatitis.Methods The clinical data of 116 patients with acute pancreatitis admitted to the hospital from April 2017 to May 2019 were retrospectively collected.According to different treatment methods,they were divided into a control group(using conventional treatment),48 cases and a study group(colon dialysis treatment)68 cases.The clinical symptoms recovery time,serum index levels,APACHEⅡscores and complications before and after treatment were compared between the two groups of patients.Results The study group's abdominal distension,abdominal pain,gastrointestinal function and serum amylase recovery time were significantly shorter than those of the control group,the difference was statistically significant(P<0.05);there was no difference in serum index levels and APACHEⅡscores between the two groups before treatment(P>0.05),after treatment the scores of TNF-α,IL-6,IL-8,and APACHEⅡin the two groups showed a significant downward trend,while the decline in the study group was more significant,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the control group was 8.33%(4/48)and the study group was 5.88%(4/68),and there was no difference(χ^(2)=0.263,P=0.608).Conclusion Colon dialysis can speed up the recovery of patients with acute pancreatitis,improve the serum index level and APACHEⅡscore,and is an effective adjuvant treatment method.