探讨血清免疫球蛋白、红细胞免疫及外周血T淋巴细胞亚群检验对治疗小儿肺炎支原体感染的指导意义

Exploration on the Guiding Significance of Serum Immunoglobulin,Red Blood Cell Immunity and Peripheral Blood T Lymphocyte Subgroup Tests in the Treatment of Children with Mycoplasma Pneumoniae Infection

目的分析血清免疫球蛋白(简称Ig)、红细胞免疫及外周血T淋巴细胞(简称PBT)亚群检验对治疗小儿肺炎支原体(简称MP)感染的指导作用。方法A组研究对象为方便选取2018年3月—2020年3月间来该院治疗的89例MP感染患儿,B组研究对象为同期入院体检的86名健康小儿。对其进行Ig、红细胞免疫和PBT检验,对比检验结果。结果Ig指标中,A组的IgA水平为(0.75±0.22)g/L,B组为(0.71±0.20)g/L(t=1.257,P=0.210);A组的IgG水平为(9.88±0.48)g/L,B组为(10.01±0.45)g/L(t=1.847,P=0.067);A组的IgM水平为(1.88±0.31)g/L,B组为(1.10±0.28)g/L(t=17.448,P<0.001)。红细胞免疫指标中,A组的红细胞C3b受体花环率(简称RBC-C3bRR)水平为(10.25±1.33)%,B组为(13.85±1.37)%(t=17.638,P<0.001);A组的免疫黏附促进因子(简称RFEF)水平(57.68±4.21)%,B组为(70.12±4.26)(t=19.428,P<0.001);A组的红细胞免疫复合物花环率(简称RBC-ICR)水平为(5.22±0.74)%,B组为(7.69±0.78)%(t=21.496,P<0.001);A组的免疫黏附抑制分子(简称FEIR)水平为(31.66±1.57)%,B组为(20.79±1.48)%(t=47.095,P<0.001)。PBT亚群指标中,A组的CD4+水平为(34.41±7.25)%,B组为(42.36±7.14)%(t=7.306,P<0.001);A组的CD3+水平为(60.12±5.24)%,B组为(71.69±5.35)%(t=14.453,P<0.001);A组的CD4+/CD8+水平为(1.60±0.76)%,B组为(1.91±0.81)(t=2.612,P=0.010);A组的CD8+水平为(22.48±4.23)%,B组为(20.16±4.38)%(t=3.565,P=0.001)。结论为MR感染患儿行IgM、红细胞免疫指标、PBT亚群指标检测可发现异常情况,具有较高的诊断价值。

Objective To analyze the guiding effect of serum immunoglobulin(Ig),red blood cell immunity and peripheral blood T lymphocyte(PBT)subgroup tests on the treatment of children with Mycoplasma pneumonia(MP)infection.Methods Conveniently selected 89 children with MP infection who came to the hospital for treatment from March 2018 to March 2020 as group A,and the subjects of group B were 86 healthy children who were admitted to the hospital for physical examination during the same period.Ig,red blood cell immunity and PBT tests were performed on them,and the test results were compared.Results Among the Ig indicators,the IgA level of group A was(0.75±0.22)g/L,the group B was(0.71±0.20)g/L(t=1.257,P=0.210);the IgG level of group A was(9.88±0.48)g/L,group B was(10.01±0.45)g/L(t=1.847,P=0.067);the IgM level of group A was(1.88±0.31)g/L,group B was(1.10±0.28)g/L(t=17.448,P<0.001).Among the red blood cell immune indexes,the red blood cell C3b receptor rosette rate(RBC-C3bRR)in group A was(10.25±1.33)%,and in group B was(13.85±1.37)%(t=17.638,P<0.001);group A the level of immune adhesion promoting factor(RFEF for short)was(57.68±4.21)%,group B was(70.12±4.26)(t=19.428,P<0.001);the rosette rate of red blood cell immune complex(referred to as RBC-ICR)in group A The level was(5.22±0.74)%,group B was(7.69±0.78)%(t=21.496,P<0.001);the immunoadhesion inhibitory molecule(FEIR)level of group A was(31.66±1.57)%,group B was(20.79±1.48)%(t=47.095,P<0.001).In the PBT subgroup index,the CD4+level of group A was(34.41±7.25)%,group B was(42.36±7.14)%(t=7.306,P<0.001);the CD3+level of group A was(60.12±5.24)%,group B was(71.69±5.35)%(t=14.453,P<0.001);the CD4+/CD8+level of group A was(1.60±0.76),group B was(1.91±0.81)(t=2.612,P=0.010);the CD8+level of group A was(22.48±4.23)%,group B was(20.16±4.38)%(t=3.565,P=0.001).Conclusion The detection of the IgM,red blood cellimmunity,and PBT lymphocyte for children with MR infection can find abnormalities and has a high diagnostic value.