小续命汤结合针灸治疗脑梗塞对内皮素和降钙素基因相关肽的影响的方案研究

A study on the effect of the Xiaoxuming decoction plus acupuncture on endothelin and calcitonin gene-related peptide in patients with cerebral infarction

目的:探讨小续命汤结合针灸治疗脑梗死对内皮素和降钙素基因相关肽的影响。方法:采用随机对照方法,将符合受试标准的60例患者分组,两组各30例,对照组为基础治疗,治疗组在对照组基础上给予小续命汤,温服,一次100 mL,一日2次;以及针刺治疗:足三里、三阴交、合谷、百会穴、四神聪,补法刺入。每日1次,14 d为一个疗程。以中医疗效、美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、血内皮素(Endothelin,ET)和降钙素基因相关肽(Calcitonin Gene-Related Peptide,CGRP)为观察指标,评价临床疗效。结果:两组患者评价指标比较,治疗前组间差异无显著性意义(P>0.05),治疗前后组内比较及治疗14 d后与对照组比较,差异均有显著性意义(P<0.05)。结论:初步表明小续命汤结合针灸治疗脑梗死有明显疗效,对内皮素和降钙素基因相关肽有明显影响,可减低脑梗死的复发率。

Objective:To explore the effect of the Xiaoxuming decoction(小续命汤)plus acupuncture on endothelin and calcitonin gene-related peptide in patients with cerebral infarction.Methods:The control group was given basic treatment,and the treatment group was treated with the Xiaoxuming decoction plus acupuncture at Zusanli(足三里),Sanyinjiao(三阴交),Hegu(合谷),Baihui(百会穴),Sishencong(四神聪)more.Results:There were significant differences in evaluation indexes between before and after treatment in two groups and 14 days after treatment(P<0.05).Conclusion:The Xiaoxuming decoction plus acupuncture shows an obvious effect on cerebral infarction,has obvious influence on ET and CGRP,and reduces the recurrence rate of cerebral infarction.