左归疏肝汤加减治疗多囊卵巢综合征不孕症的效果分析

The effects of the Zuogui Shugan decoction on infertility from polycystic ovary syndrome

目的:分析左归疏肝汤加减对多囊卵巢综合征(Poycystic Ovary Syndrome,PCOS)不孕症的疗效。方法:采用分层抽样法抽选2012年1月-2018年12月我院接收的80例PCOS不孕症患者纳入本次实验,并用均等双盲划分法将其中40例纳入对照组(按常规开展药物治疗),剩余40例纳入观察组(于对照组前提下加以左归疏肝汤),观察两组总有效率、排卵及妊娠情况、治疗前后促黄体生成激素(Luteinizing Hormone,LH)、促卵泡生成激素(Follicle Stimulating Hormone,FSH)、雌二醇(Estradiol,E2)及睾酮(Testosterone,T)水平和中医症状积分。结果:观察组治疗有效率比对照组更高(P<0.05)。观察组出现优势卵泡、排卵及临床妊娠人数比对照组更多(P<0.05);两组早期流产人数差异不显著(P>0.05)。治疗前,两组LH、FSH、T及E2水平差异不显著(P>0.05);治疗后,观察组LH、FSH、T及E2水平均低于对照组(P<0.05)。治疗前,两组在情绪抑郁、痛经、小腹胀痛、乳房胀痛以及喜太息方面的中医症状积分差异不显著(P>0.05);治疗后,观察组在情绪抑郁、痛经、小腹胀痛、乳房胀痛以及喜太息方面的中医症状积分比对照组更低(P<0.05)。结论:左归疏肝汤加减对PCOS不孕症疗效明显,能提升排卵率及妊娠率,增加优势卵泡数,降低性激素水平,改善临床症状,值得采用。

Objective:To analyze the effects of the Zuogui Shugan decoction(左归疏肝汤)on infertility from PCOS.Methods:80 patients were divided into two groups according to the equal double-blind division method.The control group was treated with routine medicines,and the observation group received the Zuogui Shugan decoction more.Results:The efficacy in the observation group was higher than that in the control group(P<0.05).The number of dominant follicles,ovulation and clinical pregnancy in the observation group was more than the control group(P<0.05).The difference between the groups in the number of early abortions was not significant(P>0.05).After treatment,the LH,FSH,T and E2 in the observation group were lower(P<0.05).After treatment,the TCM symptoms(including depression,dysmenorrhea,abdominal distension and pain,breast tenderness,and often sigh)scores in the observation group were lower(P<0.05).Conclusion:The Zuogui Shugan decoction shows significant effects on infertility from PCOS,can increase the ovulation and pregnancy of patients,increase the number of dominant follicles,reduce sex hormones levels,ameliorate the clinical symptoms,and is worthy of application.