血清超敏C反应蛋白、白细胞计数、淋巴细胞及中性粒细胞计数在新型冠状病毒肺炎诊断中的价值

Diagnostic value of the serum levels of high-sensitivity C-reactive protein, WBC,lymghocyte and neutrophil counts in COVID-19

目的探讨血清超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、淋巴细胞(LY)及中性粒细胞计数(NT)在诊断新型冠状病毒肺炎(简称新冠肺炎)中的价值。方法选取我院2020年6月至8月肺部感染患者72例,根据感染病原纳入新冠病毒组(36例)和细菌组(36例),同时选取体检科30名健康体检者纳入健康对照组,测定并比较各组患者的血清hs-CRP、WBC、LY及NT,计算并绘制4个指标的灵敏度、特异度和受试者特征(ROC)曲线。结果三组患者血清hs-CRP、WBC、LY及NT测定值比较,组间差异均有统计学意义(P<0.01)。4个指标联合诊断新冠肺炎的ROC曲线下面积最大(0.994),其灵敏度(100%)和特异度(94.4%)也最高。结论血清hs-CRP、WBC、LY及NT在诊断新冠肺炎中都具有一定的价值,4个指标联合诊断新冠肺炎感染可能的灵敏度和特异度最高。

Objective To investigate the diagnostic value of the count of serum hypersensitive C-reactive protein(serum hs-CRP)and white blood cell(WBC),lymphocyte(LY)and neutrophil(NT)in coronavirus disease 2019(COVID-19).Methods Seventy-two patients of pulmonary infection from June to August 2020 were divided into the experimental group(36 cases)and bacterial group(36 cases)according to the infection pathogen,and 30 healthy people were set as the control group.The serum hs-CRP,WBC,LY and NT were measured and compared among three groups,and the sensitivity,specificity and receiver operating characteristic(ROC)curves of four indexes were calculated and plotted.Results The differences of the serum hs-CRP,WBC,LY and NT among three groups were statistically significant(P<0.01).When the combination of four indicators was used to diagnose the COVID-19,the area under the ROC curve of the combination were 0.994,and their sensitivity(100%)and specificity(94.4%)were the highest.Conclusions The serum hs-CRP,WBC,LY and NT have certain diagnostic value in COVID-19.Moreover,the sensitivity and specificity of the combination of four indicators are higher.