米非司酮联合左炔诺孕酮宫内节育系统治疗子宫出血的有效性及对维生素A、维生素E的影响

Efficacy of Mifepristone Combined With Levonorgestrel Intrauterine Birth Control System in the Treatment of Uterine Bleeding and its Effect on Vitamin A,E

目的探讨分析米非司酮联合左炔诺孕酮宫内节育系统治疗子宫出血的有效性及对维生素A、E的影响。方法选2019年4月-2020年3月入医院治疗的功能失调性子宫出血患者100例,依据治疗方案的不同分组。对照组米非司酮治疗,研究组米非司酮联合左炔诺孕酮宫内节育系统治疗。对比两组患者卵泡早期子宫内膜厚度、月经量、血红蛋白浓度、维生素A、E水平,两组治疗效果对比以及对比两组患者药物不良反应状况。结果经治疗研究组患者月经量、卵泡早期子宫内膜厚度均低于对照组,维生素A、E水平、血红蛋白浓度高于对照组(P<0.05);研究组疗效好于对照组(P<0.05);研究组不良反应几率与对照组的差异无统计学意义(P>0.05)。结论对对功能失调性子宫出血患者应用米非司酮联合左炔诺孕酮宫内节育系统治疗,临床疗效显著,可调节月经量、卵泡早期子宫内膜厚度、维生素A、E及血红蛋白浓度,且不会加重药物不良反应。

Objective To analyze the efficacy of mifepristone combined with levonorgestrel intrauterine birth control system in the treatment of uterine bleeding and the effect on vitamin A,E.Methods A total of 100 patients with dysfunctional uterine bleeding who were admitted to the hospital for treatment from April 2019 to March 2020 were selected and divided into different groups according to different treatment regimens.The control group was treated with mifepristone,and the research group was treated with mifepristone combined with levonorgestrel intrauterine birth control system.The endometrium thickness,menstrual volume,hemoglobin concentration and vitamin A,E level in early follicular stage were compared between the two groups,the treatment effect was compared between the two groups,and the adverse drug reactions were compared between the two groups.Results After treatment,the menstrual volume,early follicular endometrial thickness of the study group was lower than the control group,and vitamin A,E level of the study group were higher than those of the control group,and the hemoglobin concentration was higher than that of the control group(P<0.05);the curative effect of the study group was better than that of the control group(P<0.05);there was no significant difference in the probability of adverse reactions between the study group and the control group(P>0.05).Conclusion Mifepristone combined with levonorgestrione intrauterine birth control system was applied to patients with dysfunctional uterine bleeding,and the clinical effect was significant.It could regulate menstrual volume,early follicular endometrial thickness,vitamin A,E and hemoglobin concentration,and would not aggravate adverse drug reactions.