单增李斯特菌生物膜形成及其调控机制研究进展

Advances on the formation and regulation mechanism of Listeria monocytogenes biofilm

单增李斯特菌是一种重要的食源性致病菌,极易在食品接触表面形成难以清除的生物膜,导致食品持续性的污染。细菌生物膜在形成量、活细菌数量、微观结构等方面受到环境因素及菌株自身特性的影响。在单增李斯特菌的生物膜形成过程中,多种调控机制发挥着重要的作用。该文介绍了细菌生物膜的形成过程及影响单增李斯特菌生物膜形成的重要因素,简述了与单增李斯特菌生物膜相关的基因调控、胞外聚合物质分泌与群体感应系统调节的研究进展,有助于更好地理解其生物膜形成的复杂生理过程,为单增李斯特菌生物膜的污染及防控提供一定参考。

Listeria monocytogenes is an important foodborne pathogen that is capable of developing stubborn biofilm on the surface of food processing equipment and cause continuous contamination of foods.Environmental factors and strain characteristics could affect the formation,number of viable bacteria and the microstructure of biofilm.Moreover,various regulatory mechanisms of L.monocytogenes may play an important role in its biofilm formation.The stage of bacterial biofilm formation and the important factor affecting L.monocytogenes biofilm formation were illustrated.Then the formation mechanism was discussed,including gene regulation,extracellular polymeric substance secretion,and quorum sensing system.This research may help understand the complex physiological process of biofilm formation for further prevention and control of L.monocytogenes biofilm.