阿托伐他汀联合氯沙坦治疗老年高血压效果及对颈动脉硬化程度影响

The effect of atorvastatin combined with losartan in the treatment of elderly hypertension and its influence on the degree of carotid arteriosclerosis

目的探讨阿托伐他汀联合氯沙坦对老年高血压患者进行治疗的疗效及对颈动脉硬化影响。方法在2018年4月~2020年4月间收治的高血压合并颈动脉硬化患者中抽取150例作为研究对象,随机分为对照组与研究组,对照组口服氯沙坦钾片治疗,研究组同时联合阿托伐他汀钙治疗,均连续治疗2个月,检测治疗前、后患者血压、血脂情况,并评估其颈动脉硬化程度,统计治疗期间药物不良反应情况。结果对照组患者经治疗后仅DBP、SBP明显降低,血脂指标及颈动脉硬化指标均无明显改善,研究组患者各颈动脉硬化及TG、TC及LDL-C、DBP、SBP指标水平均明显下降,HDL-C水平明显升高,且与对照组比较差异有统计学意义(P<0.05)。结论阿托伐他汀与氯沙坦联合用于老年高血压患者治疗可有效控制血压水平,调节血脂状态,同时减轻颈动脉硬化程度,且不会增加临床药物不良反应,安全性较高。

Objective To explore and analyze the effect of atorvastatin combined with losartan on elderly hypertensive patients and its effect on carotid atherosclerosis.Methods 150 patients with hypertension and carotid atherosclerosis admitted to hospital from April 2018 to April 2020 were selected as the research object,and they were randomly divided into the control group and the research group.The control group was treated with losartan potassium tablets orally,the research group was combined with atorvastatin calcium treatment at the same time,and both were treated continuously for 2 months.The blood pressure and blood lipids of the patients before and after the treatment were detected,and the degree of carotid arteriosclerosis was evaluated,and the adverse drug reactions during the treatment were counted.Results After treatment in the control group,only DBP and SBP were significantly reduced,but there was no significant improvement in blood lipids and carotid atherosclerosis.In the research group,carotid atherosclerosis and TG,TC,LDL-C,DBP,SBP index levels were obvious decrease,the level of HDL-C increased significantly,and it was statistically significant with the control group(P<0.05).Conclusion The combined treatment of atorvastatin and losartan in the treatment of elderly hypertensive patients can effectively control blood pressure levels,regulate blood lipid status,and reduce carotid arteriosclerosis,without increasing clinical drug adverse reactions,and has high safety.